2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE

CAS NO.：341-88-8
Empirical Formula: C16H21NO2
Molecular Weight: 259.34
MDL number: MFCD00057295
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 09:01:56

What is 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE?

Description

HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR).

The Uses of 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE

HQNO is a streptomycin antagonist. A naturally occurring antagonist of dihydrostreptomycin.

What are the applications of Application

HQNO is a high affinity respiratory chain inhibitor of quinone oxidation and Zn(II) described to reduce oxygen in and the activity of proton pumps.

Definition

ChEBI: 2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a monohydroxyquinoline and a quinoline N-oxide.

References

References/Citations 1) Nakayama?et al. (1999),?Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+?toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus; Biol. Pharm. Bull.,?221064

Properties of 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE

Melting point:	156-157°
Boiling point:	445.8±37.0 °C(Predicted)
Density	1.09±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in DMSO (up to 8 mg/ml with warming), or in Ethanol (up to 13 mg/ml with warming).
form	White to off-white crystalline solid.
pka	1.07±0.40(Predicted)
color	White
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Safety information for 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.