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HomeProduct name list2-Fluoroadenine

2-Fluoroadenine

Synonym(s):2-Fluoro-7(9)H-purin-6-ylamine

  • CAS NO.:700-49-2
  • Empirical Formula: C5H4FN5
  • Molecular Weight: 153.12
  • MDL number: MFCD01632749
  • EINECS: 624-159-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
2-Fluoroadenine Structural

What is 2-Fluoroadenine?

Description

2-Fluoroadenine is a purine nucleoside analog which has been investigated for suicide gene therapy for human malignancy. It has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro. It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 μM.

Chemical properties

white to light yellow crystal powder

The Uses of 2-Fluoroadenine

2-Fluoroadenine is a fluorinated heterocyclic 2-ring compound. It is the base moiety for many carbocyclic and acyclic nucleoside analogues, which may be used in antineoplastic studies. 2-Fluoroadenine has been used as an intermediate for antineoplastic drugs such as fludarabine. fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia.

The Uses of 2-Fluoroadenine

A purine nucleoside phosphorylase gene therapy for human malignancy.

What are the applications of Application

2-Fluoroadenine is a purine nucleoside analog which has been investigated for suicide gene therapy

Definition

ChEBI: 2-fluoroadenine is an organofluorine compound that is adenine in which the hydrogen at position 2 (the carbon between the two nitrogens of the pyrimidine ring) is replaced by a fluorine. It has a role as an antineoplastic agent. It is an organofluorine compound and a member of purines.

Properties of 2-Fluoroadenine

Melting point: >350 °C(lit.)
Boiling point: 239.6±50.0 °C(Predicted)
Density  2.05±0.1 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  DMSO (Sparingly, Sonicated, Heated), Methanol (Slightly, Heated)
form  Solid
pka 6.84±0.20(Predicted)
color  White to Light Yellow
CAS DataBase Reference 700-49-2(CAS DataBase Reference)

Safety information for 2-Fluoroadenine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Fluoroadenine

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