2-Fluoro-4-methylpyridine
Synonym(s):2-Fluoro-4-picoline
- CAS NO.：461-87-0
- Empirical Formula: C6H6FN
- Molecular Weight: 111.12
- MDL number: MFCD00041224
- EINECS: 625-585-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 2-Fluoro-4-methylpyridine ?
Chemical properties
Clear colourless to light yellow liquid
The Uses of 2-Fluoro-4-methylpyridine
2-Fluoro-4-methylpyridine may be used in the preparation of:
- 2-Fluoro-4-(iodomethyl)pyridine
- 4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydroimidazol-2-thione
- 2-fluoro-4-pyridinemethanol
- 2-fluoro-4-pyridinemethanol, 4-methylbenzenesulfonate
- 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
- 2-fluoro-3-iodo-5-methylpyridine
- 2-fluoro-4-pyridinecarboxylic acid
General Description
2-Fluoro-4-methylpyridine, also known as 2-fluoro-4-picoline, can be prepared based on Talik′s procedure from 2-amino-5-methylpyridine via diazotization. The effect of substituents on spectral properties of 2-fluoro-6-methylpyridine has been investigated based on 13C NMR, UV and IR spectral data.
Properties of 2-Fluoro-4-methylpyridine
| Boiling point: | 160-161 °C (lit.) |
| Density | 1.078 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Liquid |
| pka | 0.24±0.10(Predicted) |
| Specific Gravity | 1.078 |
| color | Colorless to pale yellow |
| BRN | 107086 |
| CAS DataBase Reference | 461-87-0(CAS DataBase Reference) |
Safety information for 2-Fluoro-4-methylpyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Fluoro-4-methylpyridine
| InChIKey | ZBFAXMKJADVOGH-UHFFFAOYSA-N |
2-Fluoro-4-methylpyridine manufacturer
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