5-Bromo-2-fluoropyridine
- CAS NO.：766-11-0
- Empirical Formula: C5H3BrFN
- Molecular Weight: 175.99
- MDL number: MFCD01863742
- EINECS: 629-380-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-02 14:14:00
What is 5-Bromo-2-fluoropyridine?
Description
5-Bromo-2-fluoropyridine is a halogenated pyridine that has been used as a molecular scaffold for many Active Pharmaceutical Ingredients (APIs) such as Neuropeptide Y Receptor Y5 Inhibitors, SARS-CoV-2 Major Protease Inhibitors, and Indoleamine-2,3-Dioxygenase-1 Inhibitors in cancer immunotherapy. 5-Bromo-2-fluoropyridine is also an ideal building block for semiconductors, due to its aromaticity and electron deficiency. A host material of 5-(5-(2,4,6-triiso-propylphenyl)pyridin-2-yl)-5H-benzo[d]benzo-[4,5]imidazo[1,2-a]imidazole is synthesized from 5-bromo-2-fluoropyridine for OLED applications.
Chemical properties
5-Bromo-2-fluoropyridine is a colourless or yellowish liquid compound with a density of 1.71 g/cm3 at 25° C; boiling point of 162-164° C (lit.) at 750 mmHg; stored at room temperature.
The Uses of 5-Bromo-2-fluoropyridine
2-Fluoro-5-bromopyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. Also used in the synthesis of benzofurano[3,2-d]pyrimidin-2-one derived inhbitors.
Properties of 5-Bromo-2-fluoropyridine
| Boiling point: | 162-164 °C750 mm Hg(lit.) |
| Density | 1.71 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 165 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Liquid |
| pka | -2.79±0.10(Predicted) |
| Specific Gravity | 1.710 |
| color | Clear colorless yellow |
| BRN | 1363171 |
| CAS DataBase Reference | 766-11-0(CAS DataBase Reference) |
Safety information for 5-Bromo-2-fluoropyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Bromo-2-fluoropyridine
| InChIKey | MYUQKYGWKHTRPG-UHFFFAOYSA-N |
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