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HomeProduct name list2-Fluoro-4-hydroxybenzaldehyde

2-Fluoro-4-hydroxybenzaldehyde

2-Fluoro-4-hydroxybenzaldehyde Structural

What is 2-Fluoro-4-hydroxybenzaldehyde?

The Uses of 2-Fluoro-4-hydroxybenzaldehyde

2-Fluoro-4-hydroxybenzaldehyde is a useful reagent for preparation of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.

The Uses of 2-Fluoro-4-hydroxybenzaldehyde

2-Fluoro-4-hydroxybenzaldehyde is mainly used as an intermediate for physiologically active compounds such as pharmaceuticals or pesticides and is a wide range of organic building blocks. Its structure contains fluorine, aldehyde groups, and phenolic hydroxyl groups, and these groups can add or replace other functional groups.

Synthesis

Preparation of 2-fluoro-4-hydroxybenzaldehyde involves: (1) mixing 3-fluorophenol (I), potassium carbonate, and 2-bromopropane in an organic solvent, and heating to react to obtain 1-fluoro-3-isopropoxybenzene (II); (2) dissolving compound (II) in an organic solvent and reacting with a brominating reagent to obtain 1-bromo-2-fluoro-4-isopropoxybenzene (III); (3) dissolving compound (III) in tetrahydrofuran, dripping isopropylmagnesium chloride/tetrahydrofuran solution at -10°C to 0°C, adding dimethylformamide to react after Grignard exchange to obtain 2-fluoro-4-isopropoxybenzaldehyde (IV); and (4) reacting compound (IV) with boron trichloride and deprotecting. 2-Fluoro-4-hydroxybenzaldehyde

Properties of 2-Fluoro-4-hydroxybenzaldehyde

Melting point: 168-170°C
Boiling point: 254.2±20.0 °C(Predicted)
Density  1.350±0.06 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
pka 6.78±0.18(Predicted)
color  Light tan
InChI InChI=1S/C7H5FO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H
CAS DataBase Reference 348-27-6(CAS DataBase Reference)

Safety information for 2-Fluoro-4-hydroxybenzaldehyde

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 2-Fluoro-4-hydroxybenzaldehyde

InChIKey ONRPXRPUBXXCCM-UHFFFAOYSA-N
SMILES C(=O)C1=CC=C(O)C=C1F

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