2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
Synonym(s):2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride;Dimethyl[(2-oxocyclohexyl)methyl]ammonium chloride
- CAS NO.:42036-65-7
- Empirical Formula: C9H18ClNO
- Molecular Weight: 191.7
- MDL number: MFCD00102580
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-12 10:29:45
What is 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride?
Chemical properties
white crystalline powder
The Uses of 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
An impurity found in Tramadol (T712500).
Synthesis
0.982 g (1.03 mL, 10.0 mmol) cyclohexanone, 0.360 g (12.0 mmol) paraformaldehyde, 0.816 g (10.0 mmol) dimethylammonium chloride and 4 mL ethanol are filled in a 25 mL round bottom flask with reflux condenser and magnetic stir bar. 2 drops of conc. hydrochloric acid is added, and the mixture is heated under stirring for 4 hours under reflux. The hot solution is filtered in a round bottom flask, and the solvent is evaporated by the rotary evaporator. The residue is dissolved in 2 mL ethanol under heating. At room temperature, 20 mL acetone is added to the solution. For complete crystallization, the solution is stored overnight in the freezer compartment. The crystallized crude product 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride is sucked off over a Buechner funnel and dried in the desiccator over silica gel.
Properties of 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
Melting point: | 147-151 °C |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Crystalline Powder |
color | White |
Water Solubility | soluble |
InChI | InChI=1S/C9H17NO.ClH/c1-10(2)7-8-5-3-4-6-9(8)11;/h8H,3-7H2,1-2H3;1H |
CAS DataBase Reference | 42036-65-7(CAS DataBase Reference) |
Safety information for 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride
InChIKey | CLVHTSWMNNSUSH-UHFFFAOYSA-N |
SMILES | C1(CN(C)C)CCCCC1=O.Cl |
Abamectin manufacturer
KARPSCHEM LABORATORIES PVT. LTD.
SHREE GANESH CHEMICALS
DL Intrachem
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