2-Diethylaminoethylchloride hydrochloride

Synonym(s):2-(Diethylamino)ethyl chloride hydrochloride;2-Chloro-N,N-diethylethylamine hydrochloride;2-Chlorotriethylamine hydrochloride

CAS NO.：869-24-9
Empirical Formula: C6H15Cl2N
Molecular Weight: 172.1
MDL number: MFCD00012519
EINECS: 212-786-4
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:56

2-Diethylaminoethylchloride hydrochloride Structural

What is 2-Diethylaminoethylchloride hydrochloride?

Chemical properties

2-Diethylaminoethylchloride hydrochloride is colourless to beige crystals

The Uses of 2-Diethylaminoethylchloride hydrochloride

2-Diethylaminoethylchloride hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet

The Uses of 2-Diethylaminoethylchloride hydrochloride

2-Chloro-N,N-diethylethylamine hydrochloride (65% in water) (DEC 65) is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet

The Uses of 2-Diethylaminoethylchloride hydrochloride

2-Chloro-N,N-diethylethylamine hydrochloride can be used as an alkylating reagent for the synthesis of:

Substituted oxindole derivatives to be used as growth hormone secretagogs.
1-Substituted-5,6-dinitrobenzimidazoles with antimicrobial and antiprotozoal activities.
Thiophene containing triarylmethane (TRAM) derivatives to be used as antitubercular agents.
Tris(2-(diethylamino)ethyl)amine to be used as a catalyst in combination with CuBr (Et₆TREN/CuBr) for atom transfer radical polymerization of n-butyl acrylate.

It can also be used for the derivatization of chitosan to incorporate aminofunctionality onto it at C-6 position.

Purification Methods

Crystallise the salt from absolute MeOH (to remove highly coloured impurities). [Beilstein 4 III 240.]

Properties of 2-Diethylaminoethylchloride hydrochloride

Melting point:	50-53 °C(lit.)
Boiling point:	255 °C(lit.)
Density	1.1919 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.6000 (estimate)
Flash point:	186 °F
storage temp.	Poison room
solubility	methanol: 0.1 g/mL, clear, colorless
form	Crystalline Powder
color	White to slightly beige
PH	5 (100g/l, H2O, 20℃)
Water Solubility	2000 g/L (20 ºC)
Sensitive	Moisture Sensitive
BRN	3591991
Stability:	Hygroscopic, Moisture Sensitive
CAS DataBase Reference	869-24-9(CAS DataBase Reference)
EPA Substance Registry System	Diethyl-(2-chloroethyl)amine hydrochloride (869-24-9)

Safety information for 2-Diethylaminoethylchloride hydrochloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H300:Acute toxicity,oral H314:Skin corrosion/irritation H341:Germ cell mutagenicity H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.