2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
Synonym(s):2-Dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl
- CAS NO.:213697-53-1
- Empirical Formula: C26H36NP
- Molecular Weight: 393.54
- MDL number: MFCD02183572
- EINECS: 606-749-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-12-13 16:54:32
What is 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl?
Description
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. It binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains.
Chemical properties
white to light yellow crystals or
The Uses of 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl can act as ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chlorides.
The Uses of 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
suzuki reaction
The Uses of 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
Effective ligand in the Pd-catalyzed arylation of ester enolates
What are the applications of Application
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylacts as a growth regulator by binding to Toll-like receptor 4 (TLR4), which is important in cytokine signaling. It also inhibits allyl carbonate production and cross coupling reactions between aryl chlorides and nitrogen atoms or amines. It has an inhibitory effect on depression, but this effect is not related to its inhibitory effect on bromodomains.
Properties of 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
Melting point: | 121-124 °C(lit.) |
Boiling point: | 539.6±43.0 °C(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
form | crystal |
pka | 5.04±0.18(Predicted) |
color | white |
Water Solubility | Insoluble |
Sensitive | Air Sensitive |
CAS DataBase Reference | 213697-53-1(CAS DataBase Reference) |
Safety information for 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
InChIKey | ZEMZPXWZVTUONV-UHFFFAOYSA-N |
New Products
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