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HomeProduct name list2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

Synonym(s):2-Dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl

  • CAS NO.:213697-53-1
  • Empirical Formula: C26H36NP
  • Molecular Weight: 393.54
  • MDL number: MFCD02183572
  • EINECS: 606-749-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-12-13 16:54:32
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Structural

What is 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl?

Description

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. It binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains.

Chemical properties

white to light yellow crystals or

The Uses of 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl can act as ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chlorides.

The Uses of 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

suzuki reaction

The Uses of 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

Effective ligand in the Pd-catalyzed arylation of ester enolates

What are the applications of Application

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylacts as a growth regulator by binding to Toll-like receptor 4 (TLR4), which is important in cytokine signaling. It also inhibits allyl carbonate production and cross coupling reactions between aryl chlorides and nitrogen atoms or amines. It has an inhibitory effect on depression, but this effect is not related to its inhibitory effect on bromodomains.

Properties of 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

Melting point: 121-124 °C(lit.)
Boiling point: 539.6±43.0 °C(Predicted)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
form  crystal
pka 5.04±0.18(Predicted)
color  white
Water Solubility  Insoluble
Sensitive  Air Sensitive
CAS DataBase Reference 213697-53-1(CAS DataBase Reference)

Safety information for 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

InChIKey ZEMZPXWZVTUONV-UHFFFAOYSA-N

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