2'-Deoxyuridine 5'-monophosphate disodium salt
Synonym(s):dUMP
- CAS NO.:42155-08-8
- Empirical Formula: C9H14N2NaO8P
- Molecular Weight: 332.18
- MDL number: MFCD00065282
- EINECS: 255-687-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-02-07 18:17:11
What is 2'-Deoxyuridine 5'-monophosphate disodium salt?
Description
2'-Deoxyuridine 5'-monophosphate disodium salt is a nucleoside analog that inhibits the synthesis of DNA and RNA by inhibiting the enzyme thymidylate synthase, which prevents the formation of dTMP from deoxyuridine 5'-triphosphate. 2'-Deoxyuridine 5'-monophosphate disodium salt has been shown to be effective in treating squamous cell cancer and hyperproliferative diseases such as chronic myelogenous leukemia. 2'-Deoxyuridine 5'-monophosphate disodium salt is also used as an antiviral agent against HIV, herpes simplex virus, and varicella zoster virus.
The Uses of 2'-Deoxyuridine 5'-monophosphate disodium salt
2?-Deoxyuridine 5?-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
What are the applications of Application
2′-Deoxyuridine 5′-monophosphate disodium salt is a reference substrate for dUMP analogs
General Description
2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).
Biochem/physiol Actions
2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
Properties of 2'-Deoxyuridine 5'-monophosphate disodium salt
storage temp. | -20°C |
solubility | PBS (pH 7.2): 1 mg/ml |
form | Powder |
color | White to Off-white |
Water Solubility | Soluble in water. |
CAS DataBase Reference | 42155-08-8(CAS DataBase Reference) |
Safety information for 2'-Deoxyuridine 5'-monophosphate disodium salt
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2'-Deoxyuridine 5'-monophosphate disodium salt
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