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HomeProduct name list2-Deoxy-D-galactose

2-Deoxy-D-galactose

Synonym(s):2-Deoxy-D-lyxohexose;2-Deoxy-D-galactose - CAS 1949-89-9 - Calbiochem

  • CAS NO.:1949-89-9
  • Empirical Formula: C6H12O5
  • Molecular Weight: 164.16
  • MDL number: MFCD00014649
  • EINECS: 217-765-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-17 21:30:02
2-Deoxy-D-galactose Structural

What is 2-Deoxy-D-galactose?

Chemical properties

White Crystalline Solid

The Uses of 2-Deoxy-D-galactose

2-Deoxy-D-galactose is used as an inhibitor of fucosylation, which is a process of adding hexose deoxy sugar units to a molecule. It is used for studying galactose uptake into Escherichia coli and also for competitive elution of Anadarin P lectin (a galactosyl-binding lectin from blood clam).

What are the applications of Application

2-Deoxy-D-galactose is an analog of hexose that inhibits fucosylation

Definition

ChEBI: 2-deoxy-D-galactose is a deoxygalactose. It is functionally related to an aldehydo-D-galactose and a D-galactose.

General Description

2-Deoxy-D-galactose is a glucose analog that shows a wide range of biological activities such as inhibition of glycolysis and thereby tumor growth, interference with the biosynthetic processing of glycoproteins, antiviral activity, and hepatotoxicity. It is being extensively studied as trapping agents for phosphate and uridylate in mammalian cells due to its ability to interfere in the phosphate and nucleotide metabolism.

Purification Methods

Crystallise 2-deoxy-D-galactose from MeOH or diethyl ether. The aniline derivative has m 142-143o, [ ] D 16.5 -149o (c 0.8, pyridine). [Overend et al. J Chem Soc 671, 675 1950 and 992 1951.] A 30% equilibrium solution at 31o in D2O contains 40% -pyranose, 44% pyranose, 8% -furanose and 8% -furanose forms as estimated by 1HNMR spectroscopy [Angyal & Pickles Aust J Chem 25 1711 1972]. [Beilstein 1 IV 4283.]

Properties of 2-Deoxy-D-galactose

Melting point: 107-110 °C(lit.)
Boiling point: 211.61°C (rough estimate)
alpha  57 º (c=3.7, H20 NH3)
Density  1.1738 (rough estimate)
refractive index  1.4230 (estimate)
storage temp.  Sealed in dry,2-8°C
solubility  Methanol, Water
form  Powder
pka 13.47±0.20(Predicted)
color  White to Off-white
optical activity [α]20/D +59.7°, c = 2 in H2O
Water Solubility  Soluble in water.
BRN  1723333
CAS DataBase Reference 1949-89-9(CAS DataBase Reference)
EPA Substance Registry System D-lyxo-Hexose, 2-deoxy- (1949-89-9)

Safety information for 2-Deoxy-D-galactose

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H372:Specific target organ toxicity, repeated exposure
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Deoxy-D-galactose

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