2'-deoxy-2'-fluoro-2'-C-methylcytidine
- CAS NO.：817204-33-4
- Empirical Formula: C10H14FN3O4
- Molecular Weight: 259.23
- MDL number: MFCD13176566
- EINECS: 200-001-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 2'-deoxy-2'-fluoro-2'-C-methylcytidine?
Description
PSI-6130 is a nucleoside inhibitor of the NS5B RNA polymerase of hepatitis C virus (HCV; Ki = 4.3 μM). It inhibits HCV genotype 1b (GT-1b) Con1 and GT-1a H77 viral replication in Huh7 replicon cells using a luciferase-based assay (EC50s = 0.51 and 0.30 μM, respectively). PSI-6130 also inhibits replication of HCV GT-1b and GT-1a replicons from clinical isolates, with EC50 values ranging from 0.60 to 1.41 μM, and 0.20 to 0.43 μM, respectively, in the same assay. It has little or no activity against West Nile Virus (WNV), Dengue type 2 virus (DV), human immunodeficiency virus (HIV), or hepatitis B virus (HBV; EC90s = 46.3, >100, >100, and >10 μM, respectively).
The Uses of 2'-deoxy-2'-fluoro-2'-C-methylcytidine
PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.
Properties of 2'-deoxy-2'-fluoro-2'-C-methylcytidine
| Melting point: | 216-218℃ |
| Boiling point: | 482.4±55.0 °C(Predicted) |
| Density | 1.67 |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 12.86±0.70(Predicted) |
| color | White to Light Brown |
| Stability: | Hygroscopic |
Safety information for 2'-deoxy-2'-fluoro-2'-C-methylcytidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2'-deoxy-2'-fluoro-2'-C-methylcytidine
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