N4-Benzoylcytosine

CAS NO.：26661-13-2
Empirical Formula: C11H9N3O2
Molecular Weight: 215.21
MDL number: MFCD00239434
EINECS: 628-907-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 18:09:03

What is N4-Benzoylcytosine?

Chemical properties

White or almost white crystalline powder

The Uses of N4-Benzoylcytosine

N4-Benzoylcytosine is a reactant in the synthesis of 1'',2''-cyclopentyl nucleosides as potential antiviral agents.

The Uses of N4-Benzoylcytosine

N⁴-Benzoylcytosine may be employed for the following syntheses:

3′-C-ethynyl and 3′-C-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides
2′-C-methyl-4′-thiocytidine, via the Pummerer reaction
2′-fluorinated L-nucleoside analogs

General Description

N⁴-Benzoylcytosine is an amide and its anti-microbial activity against pathogenic microorganisms has been studied using the Disk Diffusion and the Pour Plate method. It can be synthesized via the condensation of benzoyl chloride with cytosine.

Properties of N4-Benzoylcytosine

Melting point:	>300 °C (dec.) (lit.)
Density	1.33±0.1 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Aqueous Acid (Slightly, Heated), DMSO+DCl (Slightly, Heated)
form	Solid
pka	7.75±0.10(Predicted)
color	Off-White
InChI	InChI=1S/C11H9N3O2/c15-10(8-4-2-1-3-5-8)13-9-6-7-12-11(16)14-9/h1-7H,(H2,12,13,14,15,16)
CAS DataBase Reference	26661-13-2(CAS DataBase Reference)

Safety information for N4-Benzoylcytosine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.