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HomeProduct name list2-Chloropropionic acid

2-Chloropropionic acid

Synonym(s):(±)-2-Chloropropionic acid

  • CAS NO.:598-78-7
  • Empirical Formula: C3H5ClO2
  • Molecular Weight: 108.52
  • MDL number: MFCD00004224
  • EINECS: 209-952-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-09-03 12:56:46
2-Chloropropionic acid Structural

What is 2-Chloropropionic acid?

Chemical properties

colourless liquid

The Uses of 2-Chloropropionic acid

  • 2-Chloropropionic acid is used in the preparation of propargyl 2-chloropropionate (PCP), an atom transfer radical polymerization (ATRP) initiator, by the esterification of propargyl alcohol.
  • It can be employed in the synthesis of a biologically active chitin derivative, (1-carboxyethyl) chitosan.
  • It can be treated with o-phenylenediamine phosphate to synthesize benzimidazole derivatives.

The Uses of 2-Chloropropionic acid

Intermediate for weed killers.

General Description

A pale liquid with a slight odor. Sinks in and mixes with water. Only aluminum, stainless steel or steel covered with a protective lining or coating may contact the liquid or vapor.

Air & Water Reactions

Water soluble.

Reactivity Profile

2-Chloropropionic acid is neutralized in exothermic reactions by all bases. Reacts with aqueous solutions containing a chemical base and dissolves if neutralization generates a soluble salt. May react with active metals to form gaseous hydrogen and a metal salt. May corrode or dissolve iron, steel, and aluminum parts and containers. Reacts with cyanide salts to generate gaseous hydrogen cyanide. Reacts with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides to generate flammable and/or toxic gases and heat. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts with carbonates and bicarbonates to generate a harmless gas (carbon dioxide) but some heat. Can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. May initiate polymerization reactions or catalyze other chemical reactions. Fire produces highly toxic chloride fumes [USCG, 1999].

Hazard

Combustible. Toxic by skin contact. Male reproductive damage.

Health Hazard

Harmful if inhaled. Irritating to throat. May cause severe skin and eye burns. Harmful if absorbed through skin.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

2-Chloropropionic acid on oral administration induces necrosis of granule cell layer of rat cerebellum.

Safety Profile

Poison by skin contact. A corrosive. Combustible when exposed to heat or flame. To fight fire, use water, foam, alcohol foam. When heated to decomposition it emits toxic fumes of Cl-. See also 3-CHLOROPROPIONIC ACID.

Purification Methods

Dry it with P2O5 and fractionally distil it under vacuum. [Beilstein 2 IV 745.]

Properties of 2-Chloropropionic acid

Melting point: -12--14 °C
Boiling point: 170-190 °C(lit.)
Density  1.182 g/mL at 25 °C(lit.)
vapor pressure  4 mm Hg ( 20 °C)
refractive index  n20/D 1.4345(lit.)
Flash point: 215 °F
storage temp.  Store below +30°C.
solubility  H2O: soluble
form  clear liquid
pka 2.96±0.10(Predicted)
color  Colorless to Almost colorless
PH <1 (200g/l, H2O, 20℃)
Water Solubility  freely soluble
BRN  1720259
Exposure limits ACGIH: TWA 0.1 ppm (Skin)
Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference 598-78-7(CAS DataBase Reference)
NIST Chemistry Reference Propanoic acid, 2-chloro-(598-78-7)
EPA Substance Registry System 2-Chloropropionic acid (598-78-7)

Safety information for 2-Chloropropionic acid

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H314:Skin corrosion/irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Chloropropionic acid

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