2-Chlorobenzoyl chloride
Synonym(s):2-Chlorobenzoic acid chloride;2-Chlorobenzoyl chloride
- CAS NO.:609-65-4
- Empirical Formula: C7H4Cl2O
- Molecular Weight: 175.01
- MDL number: MFCD00000660
- EINECS: 210-194-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-19 17:35:41
What is 2-Chlorobenzoyl chloride?
Chemical properties
clear colourless to very slightly yellow liquid
The Uses of 2-Chlorobenzoyl chloride
2-Chlorobenzoyl chloride, is used in organic synthesis. It is used as a pharmaceutical intermediate for eg as an intermediate of clotrimazolc, preparation of p-chlorobenzoic acid and production of trichloro-acaricide.
Definition
ChEBI: An acyl chloride consisting of benzoyl chloride having a chloro substituent in the ortho-position.
General Description
2-Chlorobenzoyl chloride reacts with aromatic amines and ammonium thiocyanate using polyethylene glycol-400 as the catalyst under the condition of solid-liquid phase-transfer catalysis to form N-aryl-N′(2-chlorobenzoyl) thioureas. 2-Chlorobenzoyl chloride causes the acylation of polystyrene during the preparation and regeneration of the polystyrene-based resin.
Synthesis
A process for preparing 2-chlorobenzoyl chloride which comprises reacting 2-chlorobenzaldehyde with chlorine in the presence of phosphorus pentachloride at a temperature of from 50° to 200° C. and wherein the 2-chlorobenzaldehyde: phosphorus pentachloride ratio is from 1:0.05 to 1:0.2. Phosphorus pentachloride (41.5 g, 0.2 mole) was added to 2-chlorobenzaldehyde (289.7 g, 2.0 mole, 97%). After the ensuing exotherm had subsided, the resulting red solution was heated to 160° C. A stream of chlorine was introduced through a sparge tube into the solution for six hours. (Gas chromatography indicated 96.5% conversion.) The solution was then cooled and distilled under reduced pressure, giving 325.4 grams of 2-chlorobenzoyl chloride, which boiled at 135° to 140° C. at 16 millimeters of mercury. The yield of 2-Chlorobenzoyl chloride was 93% (98.5% pure).
Properties of 2-Chlorobenzoyl chloride
Melting point: | -4--3 °C (lit.) |
Boiling point: | 238 °C (lit.) |
Density | 1.382 g/mL at 25 °C (lit.) |
vapor pressure | 0.1 hPa (20 °C) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Store below +30°C. |
form | Liquid |
color | Clear colorless to very slightly yellow |
explosive limit | 1.5-9.4%(V) |
Water Solubility | Soluble in acetone, ether, and alcohol. Solubility in water it decomposes. |
Sensitive | Moisture Sensitive |
BRN | 386435 |
CAS DataBase Reference | 609-65-4(CAS DataBase Reference) |
NIST Chemistry Reference | Benzoyl chloride, 2-chloro-(609-65-4) |
EPA Substance Registry System | Benzoyl chloride, 2-chloro- (609-65-4) |
Safety information for 2-Chlorobenzoyl chloride
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Chlorobenzoyl chloride
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Sima Chemicals (Sima Products)
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