2-Chlorobenzaldehyde
Synonym(s):2-Chlorobenzaldehyde
- CAS NO.:89-98-5
- Empirical Formula: C7H5ClO
- Molecular Weight: 140.57
- MDL number: MFCD00003304
- EINECS: 201-956-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 2-Chlorobenzaldehyde ?
Chemical properties
2-Chlorobenzaldehyde is a colorless to yellowish liquid with a penetrating odor. Insoluble in water, soluble in benzene, alcohol and ether. 2-Chlorobenzaldehyde is considerably more resistant to oxidation than benzaldehyde. When it is heated with sodium sulfite solution under pressure, benzaldehyde-2-sulfonic acid forms.
The Uses of 2-Chlorobenzaldehyde
2-Chlorobenzaldehyde has been used in generation of small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and thioureas.
The Uses of 2-Chlorobenzaldehyde
2-Chlorobenzaldehyde can be used to make alcohols, acids, and dyes; used in the rubber, tanning, and paper industries; used as an intermediate for optical brighteners, agricultural chemicals, and pharmaceuticals.It can also be used to prepare triphenyl methane and related dyes, organic intermediate.
Preparation
2-Chlorobenzaldehyde is produced mainly by chlorination of 2-chlorotoluene to form 2-chlorobenzal chloride, which is then subjected to acid hydrolysis. Metal salts, such as iron(III) chloride, are used as catalysts. The hydrolysis can also be accomplished using formic acid without a catalyst.
2-Chlorobenzaldehyde can also be produced by oxidation of 2-chlorobenzyl chloride with N-oxides of tertiary amines or with dilute nitric acid.
https://pubchem.ncbi.nlm.nih.gov/compound/2-Chlorobenzaldehyde
What are the applications of Application
2-Chlorobenzaldehyde is used acid zinc plating brightener, also be used for organic synthesis, agricultural pesticide and pharmaceutical industries. It is used to synthesize the acaricides clofentezine and flutenzine. 2-Chlorobenzaldehyde undergoes alkynylation with phenylacetylene in the presence of catalytic ligands and dimethylzinc at 0°C to form binaphthyl-derived amino alcohols.
Synthesis Reference(s)
Tetrahedron Letters, 34, p. 8037, 1993 DOI: 10.1016/S0040-4039(00)61444-2
General Description
2-chlorobenzaldehyde is a clear colorless to yellowish liquid. (NTP, 1992)
Air & Water Reactions
2-Chlorobenzaldehyde is moisture and light sensitive. Slightly water soluble.
Reactivity Profile
2-Chlorobenzaldehyde reacts with iron and strong oxidizers, strong bases and strong reducing agents.
Health Hazard
Symptoms of exposure to 2-Chlorobenzaldehyde may include skin, eye and upper respiratory tract irritation. This compound may cause skin, eye and respiratory tract irritation. When heated to decomposition it emits toxic fumes.
Fire Hazard
2-Chlorobenzaldehyde is combustible.
Safety Profile
Poison by intraperitoneal and intravenous routes. When heated to decomposition it emits toxic fumes of Cl-. See also ALDEHYDES and CHLORIDES.
Purification Methods
Wash it with 10% Na2CO3 solution, then fractionally distil it in the presence of a small amount of catechol as stabiliser. [Beilstein 7 H 233, 7 IV 561.]
Properties of 2-Chlorobenzaldehyde
Melting point: | 9-11 °C (lit.) |
Boiling point: | 209-215 °C (lit.) |
Density | 1.248 g/mL at 25 °C (lit.) |
vapor density | 4.84 (vs air) |
vapor pressure | 1.27 mm Hg ( 50 °C) |
refractive index | n |
Flash point: | 190 °F |
storage temp. | Store in RT |
solubility | 1.8g/l |
form | Liquid |
color | Clear colorless to light yellow |
PH | 2.9 (H2O)(saturated aqueous solution) |
Water Solubility | 0.1-0.5 g/100 mL at 24 ºC |
Sensitive | Air Sensitive |
BRN | 385877 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, iron, strong reducing agents. Moisture and light-sensitive. |
CAS DataBase Reference | 89-98-5(CAS DataBase Reference) |
NIST Chemistry Reference | Benzaldehyde, 2-chloro-(89-98-5) |
EPA Substance Registry System | 2-Chlorobenzaldehyde (89-98-5) |
Safety information for 2-Chlorobenzaldehyde
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Chlorobenzaldehyde
Abamectin manufacturer
JSK Chemicals
LANXESS India Pvt. Ltd.
S D Fine Chem Limited
Pallav Chemicals And Solvents Pvt Ltd
New Products
(R)-(-)-2-Amino-1-propanol Tetrahydro-4H-pyran-4-one Bromine 99.5% AR (4 x 500ml) Linseed Oil Extrapure Hydrogen Sulphide Solution Oxalic Acid 0.05 mol/L (0.01N) Solution EDTA 0.1 mol/L (0.2N) for 1000 ml Ferroin 0.025M Solution AR 1,2,3,4-Tetrahydrocarbazol-4-one 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Sodium Amino Salicylate Dihydrate (PAS Sodium) IP/BP/USP/EP Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Spirulina (Arthrospira platensis) Powder Trikatu Extract Thymol Oil Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride 5-NitrosalicylaldehydeRelated products of tetrahydrofuran
You may like
-
2-Chloro benzaldehyde CAS 89-98-5View Details
89-98-5 -
Ortho Chloro Benzaldehyde CASView Details
-
o-Chlorobenzaldehyde pure CAS 89-98-5View Details
89-98-5 -
OCBA-O-Chlorobenzaldehyde CAS 89-88-5View Details
89-88-5 -
2-Chlorobenzaldehyde CAS 89-98-5View Details
89-98-5 -
Ortho Chloro Benzaldehyde CASView Details
-
2-Chlorobenzaldehyde CASView Details
-
2-CHLOROBENZALDEHYDE For Synthesis CAS 89-98-5View Details
89-98-5