2-Chlorobenzothiazole

Chemical properties

CLEAR YELLOW TO YELLOW-BROWNISH LIQUID

The Uses of 2-Chlorobenzothiazole

2-Chlorobenzothiazole was used in the synthesis of:

• (RS)- and (S)-lubeluzole
• (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives
• 4H-thieno[2′,3′:4,5]pyrimido[2,1-b]benzothiazole derivatives

The Uses of 2-Chlorobenzothiazole

2-Chloro-1,3-benzothiazole is used in the synthesis of CBTs which are good building blocks for bioluminescent compounds for imaging.

Purification Methods

It is purified by fractional distillation in vacuo. The 2-chloro-3-methylbenzothiazolinium 2,4-dinitrobenzenesulfonate crystallises from Ac2O, m 162-163o(dec). [Young & Amstutz J Am Chem Soc 73 4773 1951, Brower et al. J Org Chem 19 1830 1954, Hunter & Jones J Chem Soc 2190 1930, Beilstein 27 H 44, 27 II 18, 27 III/IV 1072.]