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HomeProduct name list2-Chloro-N,N-dimethylacetamide

2-Chloro-N,N-dimethylacetamide

Synonym(s):N,N-Dimethylchloroacetamide

  • CAS NO.:2675-89-0
  • Empirical Formula: C4H8ClNO
  • Molecular Weight: 121.57
  • MDL number: MFCD00039360
  • EINECS: 220-224-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
2-Chloro-N,N-dimethylacetamide Structural

What is 2-Chloro-N,N-dimethylacetamide?

The Uses of 2-Chloro-N,N-dimethylacetamide

2-Chloro-N,N-dimethylacetamide is N,M-dialkyl amide used as an organic catalyst in the preparation of phosphorylated thiosemicarbazide.

The Uses of 2-Chloro-N,N-dimethylacetamide

2-Chloro-N,N-dimethylacetamide (N,N-dimethylchloroacetamide) was used in the synthesis of (S)-carbinoxamine.

Synthesis

In a 500 mL four-necked flask, sodium hydrogen carbonate 126.0 g (1.50 mol) and 146.8 g of toluene were added, and the mixture was stirred while cooling. The internal temperature was maintained below 5 ° C, 112.9 g (1.00 mol) of chloroacetyl chloride was added dropwise over 4 hours, and 49.6 g (1.10 mol) of dimethylamine gas was blown over 4 hours. After stirring at -2 to 1 ° C. for 1 hour, the reaction solution was filtrated under reduced pressure to remove inorganic salt crystals by filtration. The crystals were washed with 100 g of toluene, and the filtrate and washings were combined. After separating and removing the aqueous layer in the filtrate washings, the toluene layer was concentrated under reduced pressure to obtain 113.2 g (0.93 mol) of oily 2-chloro-N, N-dimethylacetamide. The yield was 93.1%.
2-Chloro-N,N-dimethylacetamide

Properties of 2-Chloro-N,N-dimethylacetamide

Melting point: 15-16 °C
Boiling point: 98-100°C/11mm
Density  1.182 g/mL at 20 °C (lit.)
refractive index  n20/D 1.479
Flash point: 98-100°C/11mm
storage temp.  Store below +30°C.
solubility  Chloroform (Slightly), Hexane (Slightly), Methanol (Slightly)
form  Liquid
pka -0.95±0.70(Predicted)
color  Clear colorless to pale yellow
BRN  969568
CAS DataBase Reference 2675-89-0(CAS DataBase Reference)

Safety information for 2-Chloro-N,N-dimethylacetamide

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H314:Skin corrosion/irritation
Precautionary Statement Codes P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Chloro-N,N-dimethylacetamide

InChIKey XBPPLECAZBTMMK-UHFFFAOYSA-N

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