2-Chloro-6-methylaniline

Synonym(s):2-Amino-3-chlorotoluene;6-Chloro-o-toluidine

CAS NO.：87-63-8
Empirical Formula: C7H8ClN
Molecular Weight: 141.6
MDL number: MFCD00007679
EINECS: 201-759-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 13:37:16

What is 2-Chloro-6-methylaniline?

Description

2-chloro-6-methylaniline is an important organic synthesis intermediate widely applied to chemical pharmacy, pesticides, and organic synthesis. In the aspects of chemical pharmacy and pesticides, 2-chloro-6-methylaniline can be used as a reaction starting material to participate in the preparation processes of tyrosine kinase inhibitors dasatinib, indazole derivatives with anti-breast cancer activity, 2-methyl-6-chlorophenyl sulfonylurea derivatives with bacteriostatic activity and the like; in the aspect of organic synthesis, 2-chloro-6-methylaniline can introduce chemical groups such as hydrazine, nitro, cyano, halogen (F, Cl, Br), and the like into an aromatic ring through diazotization reaction, thereby participating in wide chemical reactions.

Chemical properties

clear yellow to red-brown liquid

Chemical properties

The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.

The Uses of 2-Chloro-6-methylaniline

2-Chloro-6-methylaniline is a substituted aniline used in the preparation of various pharmaceutical compounds. 2-Chloro-6-methylaniline showed inhibition of the polymerization of vinyl acetate.

What are the applications of Application

2-Chloro-6-methylaniline is a substituted aniline

Preparation

A preparation method of 2-chloro-6-methylaniline takes 3-chloro-5-methyl-4-nitroaniline as a starting material, water as a solvent, and sulfuric acid as a reactant. Eliminates amino groups through diazotization reaction, reduces by hypophosphorous acid to obtain an intermediate, and finally takes iron powder as reducing nitro groups to prepare the 2-chloro-6-methylaniline through a one-pot reaction.

Potential Exposure

Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.

Shipping

UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials

Incompatibilities

Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

Properties of 2-Chloro-6-methylaniline

Melting point:	10-12 °C(lit.)
Boiling point:	215 °C(lit.)
Density	1.152 g/mL at 25 °C(lit.)
refractive index	n20/D 1.576(lit.)
Flash point:	210 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Oil
pka	2.51±0.10(Predicted)
color	Clear Colourless to Pale Purple
Water Solubility	Immiscible
BRN	774624
CAS DataBase Reference	87-63-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 2-chloro-6-methyl-(87-63-8)
EPA Substance Registry System	6-Chloro-2-methylaniline (87-63-8)

Safety information for 2-Chloro-6-methylaniline

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H341:Germ cell mutagenicity H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection.