2-CHLORO-4-PHENYLQUINAZOLINE
- CAS NO.:29874-83-7
- Empirical Formula: C14H9ClN2
- Molecular Weight: 240.69
- MDL number: MFCD01152724
- EINECS: 201-615-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-08 20:25:11
What is 2-CHLORO-4-PHENYLQUINAZOLINE?
The Uses of 2-CHLORO-4-PHENYLQUINAZOLINE
2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.
The Uses of 2-CHLORO-4-PHENYLQUINAZOLINE
2-CHLORO-4-PHENYLQUINAZOLINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).
Properties of 2-CHLORO-4-PHENYLQUINAZOLINE
Melting point: | 113.0 to 117.0 °C |
Boiling point: | 347.4±30.0 °C(Predicted) |
Density | 1.285±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
form | powder to crystal |
pka | 0.24±0.30(Predicted) |
color | White to Orange to Green |
Safety information for 2-CHLORO-4-PHENYLQUINAZOLINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-CHLORO-4-PHENYLQUINAZOLINE
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