2-CHLORO-2,2-DIFLUOROACETOPHENONE
Synonym(s):α-Chloro-α,α-difluoroacetophenone;2-Chloro-2,2-difluoro-1-phenylethanone;Chlorodifluoromethyl phenyl ketone
- CAS NO.：384-67-8
- Empirical Formula: C8H5ClF2O
- Molecular Weight: 190.57
- MDL number: MFCD00042123
- EINECS: 621-031-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-25 15:58:02
What is 2-CHLORO-2,2-DIFLUOROACETOPHENONE?
Description
Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.
The Uses of 2-CHLORO-2,2-DIFLUOROACETOPHENONE
2-Chloro-2,2-difluoroacetophenone can be used:
- As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
- As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
- As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
General Description
2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.
Properties of 2-CHLORO-2,2-DIFLUOROACETOPHENONE
| Melting point: | 102-103 °C |
| Boiling point: | 94-96 °C35 mm Hg(lit.) |
| Density | 1.293 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 163 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Difficult to mix. |
| color | Clear, colourless |
| BRN | 2251448 |
| CAS DataBase Reference | 384-67-8(CAS DataBase Reference) |
Safety information for 2-CHLORO-2,2-DIFLUOROACETOPHENONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-CHLORO-2,2-DIFLUOROACETOPHENONE
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