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HomeProduct name list2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-CHLORO-2,2-DIFLUOROACETOPHENONE

Synonym(s):α-Chloro-α,α-difluoroacetophenone;2-Chloro-2,2-difluoro-1-phenylethanone;Chlorodifluoromethyl phenyl ketone

  • CAS NO.:384-67-8
  • Empirical Formula: C8H5ClF2O
  • Molecular Weight: 190.57
  • MDL number: MFCD00042123
  • EINECS: 621-031-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-01-25 15:58:02
2-CHLORO-2,2-DIFLUOROACETOPHENONE Structural

What is 2-CHLORO-2,2-DIFLUOROACETOPHENONE?

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

The Uses of 2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-Chloro-2,2-difluoroacetophenone can be used:

  • As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
  • As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
  • As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.

Properties of 2-CHLORO-2,2-DIFLUOROACETOPHENONE

Melting point: 102-103 °C
Boiling point: 94-96 °C35 mm Hg(lit.)
Density  1.293 g/mL at 25 °C(lit.)
refractive index  n20/D 1.497(lit.)
Flash point: 163 °F
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Difficult to mix.
color  Clear, colourless
BRN  2251448
CAS DataBase Reference 384-67-8(CAS DataBase Reference)

Safety information for 2-CHLORO-2,2-DIFLUOROACETOPHENONE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-CHLORO-2,2-DIFLUOROACETOPHENONE

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