2-Carboxybenzaldehyde

Synonym(s):2-Formylbenzoic acid;3-Hydroxyphthalide;Phthalaldehydic acid

CAS NO.：119-67-5
Empirical Formula: C8H6O3
Molecular Weight: 150.13
MDL number: MFCD00003336
EINECS: 204-342-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-24 21:11:45

What is 2-Carboxybenzaldehyde?

Chemical properties

white to slightly beige crystalline powder

The Uses of 2-Carboxybenzaldehyde

2-Carboxybenzaldehyde is a carboxylated derivative of benzaldehyde which is readily converted to 2-hydroxymethyl benzoic acid by CBA dehydrogenase. 2-Carboxybenzaldehyde is a metabolite of ampicillin phthalidyl ester. It has been used to synthesize a series of N-substituted isoindolinones by reductive C-N coupling and intramolecular amidation with amines.

What are the applications of Application

2-Carboxybenzaldehyde is a metabolite of ampicillin phthalidyl ester

Definition

ChEBI: An aldehydic acid which consists of benzoic acid substituted by a formyl group at position 2.

Synthesis Reference(s)

Tetrahedron Letters, 14, p. 3535, 1973 DOI: 10.1016/S0040-4039(01)86963-X
The Journal of Organic Chemistry, 32, p. 3200, 1967 DOI: 10.1021/jo01285a061

Properties of 2-Carboxybenzaldehyde

Melting point:	94-96 °C(lit.)
Boiling point:	231.65°C (rough estimate)
Density	1,404 g/cm³
refractive index	1.4500 (estimate)
Flash point:	198°(388°F)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Crystalline Powder
pka	4.57±0.10(Predicted)
color	White to slightly beige
PH	2 (20g/l, H2O, 20℃)
Water Solubility	soluble
Sensitive	Air Sensitive
BRN	742381
Stability:	Hygroscopic
CAS DataBase Reference	119-67-5(CAS DataBase Reference)
EPA Substance Registry System	Benzoic acid, 2-formyl- (119-67-5)

Safety information for 2-Carboxybenzaldehyde

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.