2-Bromoisobutyryl Bromide

Synonym(s):2-Bromo-2-methylpropionyl bromide;BIBB

CAS NO.：20769-85-1
Empirical Formula: C4H6Br2O
Molecular Weight: 229.9
MDL number: MFCD00000122
EINECS: 244-017-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-30 18:52:02

What is 2-Bromoisobutyryl Bromide?

Chemical properties

colourless liquid

The Uses of 2-Bromoisobutyryl Bromide

2-Bromoisobutyryl bromide is used to prepare N-protected halodienamide, which provides four- and five-membered lactams in the presence of copper(I) and a tertiary amine. Further, it is used as atom transfer radical polymerization(ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide. It is also used in preparation of polycaprolactone macroinitiators through reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface.

The Uses of 2-Bromoisobutyryl Bromide

α-Bromoisobutyryl bromide has been used:

as atom transfer radical polymerization (ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide
to form an N-protected halodienamide which provided four- and five-membered lactams in the presence of copper (I) and a tertiary amine
in preparation of polycaprolactone macroinitiator via reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface

Properties of 2-Bromoisobutyryl Bromide

Boiling point:	162-164 °C(lit.)
Density	1.86 g/mL at 20 °C
refractive index	n20/D 1.507(lit.)
Flash point:	>110°C
storage temp.	Store below +30°C.
solubility	Miscible with acetone and carbon disulfide.
form	Liquid
color	Clear light yellow to yellow
Specific Gravity	1.860 (20/4℃)
Water Solubility	reacts
Sensitive	Moisture Sensitive
BRN	1746128
Stability:	Stable, but may react with moisture. Incompatible with water, strong oxidizing agents, strong bases.
CAS DataBase Reference	20769-85-1(CAS DataBase Reference)
NIST Chemistry Reference	Propanoyl bromide, 2-bromo-2-methyl-(20769-85-1)
EPA Substance Registry System	Propanoyl bromide, 2-bromo-2-methyl- (20769-85-1)

Safety information for 2-Bromoisobutyryl Bromide

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.