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HomeProduct name list2-Bromo-5-fluoropyridine

2-Bromo-5-fluoropyridine

  • CAS NO.:41404-58-4
  • Empirical Formula: C5H3BrFN
  • Molecular Weight: 175.99
  • MDL number: MFCD00234011
  • EINECS: 629-269-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-01-25 09:38:39
2-Bromo-5-fluoropyridine Structural

What is 2-Bromo-5-fluoropyridine?

Chemical properties

Light yellow Cryst

The Uses of 2-Bromo-5-fluoropyridine

2-Bromo-5-fluoropyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.

The Uses of 2-Bromo-5-fluoropyridine

2-Bromo-5-fluoropyridine can be used in the synthesis of the following:

  • 5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid
  • 5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid
It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.

What are the applications of Application

2-Bromo-5-fluoropyridine is A good starting material to be used in palladium calalyzed α-arylation of esters

Properties of 2-Bromo-5-fluoropyridine

Melting point: 30-31 °C (lit.)
Boiling point: 80-83 °C/44 mmHg (lit.)
Density  1.707±0.06 g/cm3(Predicted)
refractive index  1.5396
Flash point: 167 °F
storage temp.  Inert atmosphere,Room Temperature
form  Liquid
pka -1.63±0.10(Predicted)
color  Colorless to slightly yellow
BRN  1561456
CAS DataBase Reference 41404-58-4(CAS DataBase Reference)

Safety information for 2-Bromo-5-fluoropyridine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Bromo-5-fluoropyridine

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