2-Bromo-5-nitropyridine
- CAS NO.：4487-59-6
- Empirical Formula: C5H3BrN2O2
- Molecular Weight: 202.99
- MDL number: MFCD00006222
- EINECS: 224-777-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 2-Bromo-5-nitropyridine?
Chemical properties
Off-white to light yellow crystal.
The Uses of 2-Bromo-5-nitropyridine
2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal acetylenes.
Properties of 2-Bromo-5-nitropyridine
| Melting point: | 139-141 °C (lit.) |
| Boiling point: | 145-147 °C/10 mmHg (lit.) |
| Density | 1.8727 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| Flash point: | 145-147°C/10mm |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform, Hot Methanol |
| pka | -3.24±0.10(Predicted) |
| form | Crystalline Powder |
| color | Light yellow to light brown |
| Water Solubility | Insoluble in water. |
| BRN | 120901 |
| CAS DataBase Reference | 4487-59-6(CAS DataBase Reference) |
Safety information for 2-Bromo-5-nitropyridine
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Bromo-5-nitropyridine
| InChIKey | HUUFTVUBFFESEN-UHFFFAOYSA-N |
2-Bromo-5-nitropyridine manufacturer
JSK Chemicals
3Y
Phone:+91-9879767984
Whatsapp: +91-9879767970
product: 2-Bromo-5-nitropyridine, 98% 4487-59-6 99%
ALS India Life Sciences Pvt. Ltd
2Y
Phone:+91-8977036378
Whatsapp: +91 8008166674
product: 2-Bromo-5-nitropyridine 97.20%
Lorven Biologics Pvt Ltd
1Y
Phone:+91-8884110005
Whatsapp: +91-8884110005
product: 4487-59-6 2-bromo 5-nitro pyridine 98%
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: 2-Bromo-5-nitropyridine
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