2-Benzoylpyridine
Synonym(s):Phenyl 2-pyridyl ketone
- CAS NO.：91-02-1
- Empirical Formula: C12H9NO
- Molecular Weight: 183.21
- MDL number: MFCD00006300
- EINECS: 202-034-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is 2-Benzoylpyridine?
Chemical properties
COLOURLESS TO SLIGHTLY YELLOW CRYSTALLINE CHUNKS
The Uses of 2-Benzoylpyridine
2-Benzoylpyridine is used as a reagent to assist crosslinking in acrylic coating compounds in the polymers industry. 2-Benzoylpyridine is also a precursor for thioemicarbazone compounds that exhibit high cytotoxic activity against human leukemia cell lines and also posesses some antiinflammatory qualities.
The Uses of 2-Benzoylpyridine
Organic synthesis.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 24, p. 1061, 1987 DOI: 10.1002/jhet.5570240429
Tetrahedron Letters, 25, p. 1715, 1984 DOI: 10.1016/S0040-4039(01)81152-7
Purification Methods
Dissolve 2-benzoylpyridine in Et2O, shake it with aqueous NaHCO3, H2O, dry it over MgSO4 and evaporate. The residue solidifies on cooling. The solid can be recrystallised from pet ether. Its hydrochloride crystallises from Me2CO, m 126-127o, and the 2,4-dinitrophenylhydrazone has m 193-195o. It distils at high vacuum. [Kinkerton & Thames J Organomet Chem 24 623 1970, Beilstein 21/8 V 566.]
Properties of 2-Benzoylpyridine
| Melting point: | 41-43 °C (lit.) |
| Boiling point: | 317 °C (lit.) |
| Density | 1,556 g/cm3 |
| refractive index | 1.5880 (estimate) |
| Flash point: | 302 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline Chunks |
| pka | 2.90±0.10(Predicted) |
| color | Colorless to slightly yellow |
| Water Solubility | insoluble |
| BRN | 120283 |
| CAS DataBase Reference | 91-02-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Methanone, phenyl-2-pyridinyl-(91-02-1) |
| EPA Substance Registry System | Methanone, phenyl-2-pyridinyl- (91-02-1) |
Safety information for 2-Benzoylpyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Benzoylpyridine
2-Benzoylpyridine manufacturer
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METHANONE](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB4257792.gif)
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