2-Benzoylpyridine

Synonym(s):Phenyl 2-pyridyl ketone

CAS NO.：91-02-1
Empirical Formula: C12H9NO
Molecular Weight: 183.21
MDL number: MFCD00006300
EINECS: 202-034-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 18:01:24

What is 2-Benzoylpyridine?

Chemical properties

COLOURLESS TO SLIGHTLY YELLOW CRYSTALLINE CHUNKS

The Uses of 2-Benzoylpyridine

2-Benzoylpyridine is used as a reagent to assist crosslinking in acrylic coating compounds in the polymers industry. 2-Benzoylpyridine is also a precursor for thioemicarbazone compounds that exhibit high cytotoxic activity against human leukemia cell lines and also posesses some antiinflammatory qualities.

The Uses of 2-Benzoylpyridine

Organic synthesis.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 24, p. 1061, 1987 DOI: 10.1002/jhet.5570240429
Tetrahedron Letters, 25, p. 1715, 1984 DOI: 10.1016/S0040-4039(01)81152-7

Purification Methods

Dissolve 2-benzoylpyridine in Et2O, shake it with aqueous NaHCO3, H2O, dry it over MgSO4 and evaporate. The residue solidifies on cooling. The solid can be recrystallised from pet ether. Its hydrochloride crystallises from Me2CO, m 126-127o, and the 2,4-dinitrophenylhydrazone has m 193-195o. It distils at high vacuum. [Kinkerton & Thames J Organomet Chem 24 623 1970, Beilstein 21/8 V 566.]

Properties of 2-Benzoylpyridine

Melting point:	41-43 °C (lit.)
Boiling point:	317 °C (lit.)
Density	1,556 g/cm³
refractive index	1.5880 (estimate)
Flash point:	302 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Crystalline Chunks
pka	2.90±0.10(Predicted)
color	Colorless to slightly yellow
Water Solubility	insoluble
BRN	120283
CAS DataBase Reference	91-02-1(CAS DataBase Reference)
NIST Chemistry Reference	Methanone, phenyl-2-pyridinyl-(91-02-1)
EPA Substance Registry System	Methanone, phenyl-2-pyridinyl- (91-02-1)

Safety information for 2-Benzoylpyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.