2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
Synonym(s):;Benzoylbenzoyl-ATP;Bz-ATP;BzATP Triethylammonium Salt - CAS 112898-15-4 - Calbiochem
- CAS NO.:112898-15-4
- Empirical Formula: C30H39N6O15P3
- Molecular Weight: 816.58
- MDL number: MFCD00058547
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT?
The Uses of 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt has been used as a P2X4 receptor agonist in rat kidney sections, type I diabetes induced rats and astrocyte?neuron coculture. It has also been used as a synthetic ATP analog in isotonic E3 medium.
What are the applications of Application
BzATP triethylammonium salt is a P2X7 receptor agonist
General Description
2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate is a photoreactive analog of ATP.
Biological Activity
Prototypic P2X 7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC 50 = 0.7 μ M in HEK 293 cells). Exhibits partial agonist activity at P2X 1 (pEC 50 = 8.7) and P2Y 1 receptors and can be used as a photoaffinity label for ATPase.
Biochem/physiol Actions
2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt is a selective purinergic receptor (P2X) agonist. It is more potent than ATP at homodimeric P2X7 receptors. It also effectively activates P2X1, P2X2, and P2X3 receptors. Useful as a photoaffinity label for proteins and enzymes that bind ATP.
storage
-20°C
Properties of 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
storage temp. | -20°C |
solubility | ≤14 mg/ml in DMSO |
form | solid |
color | white to off-white |
Water Solubility | Soluble in water (supplied pre-dissolved at a concentration of 5mM) |
Safety information for 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
InChIKey | HVOVBTNCGADRTH-WBLDMZOZSA-N |
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