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HomeProduct name list2-Aminopurine

2-Aminopurine

Synonym(s):2-AP

  • CAS NO.:452-06-2
  • Empirical Formula: C5H5N5
  • Molecular Weight: 135.13
  • MDL number: MFCD00005566
  • EINECS: 207-197-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 20:21:46
2-Aminopurine Structural

What is 2-Aminopurine?

Chemical properties

white to light yellow crystal powder

The Uses of 2-Aminopurine

2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.

The Uses of 2-Aminopurine

A probe of structural dynamicas and charge transfer in DNA

The Uses of 2-Aminopurine

A probe of structural dynamics and charge transfer in DNA .

What are the applications of Application

2-Aminopurine is An inhibitor of PKR.

Definition

ChEBI: The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.

Biochem/physiol Actions

2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.

Properties of 2-Aminopurine

Melting point: 280-282 °C (lit.)
Boiling point: 238.81°C (rough estimate)
Density  1.3795 (rough estimate)
refractive index  1.7000 (estimate)
storage temp.  2-8°C
solubility  Aqueous Acid (Slightly), Methanol (Slightly, Heated)
form  Amorphous Powder
pka 8.02±0.20(Predicted)
color  Light beige
Stability: Hygroscopic
CAS DataBase Reference 452-06-2(CAS DataBase Reference)
NIST Chemistry Reference Purine, 2-amino-(452-06-2)

Safety information for 2-Aminopurine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for 2-Aminopurine

InChIKey MWBWWFOAEOYUST-UHFFFAOYSA-N

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