2-Aminopurine

Synonym(s):2-AP

CAS NO.：452-06-2
Empirical Formula: C5H5N5
Molecular Weight: 135.13
MDL number: MFCD00005566
EINECS: 207-197-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 15:53:33

What is 2-Aminopurine?

Chemical properties

white to light yellow crystal powder

The Uses of 2-Aminopurine

2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.

The Uses of 2-Aminopurine

A probe of structural dynamicas and charge transfer in DNA

The Uses of 2-Aminopurine

A probe of structural dynamics and charge transfer in DNA .

What are the applications of Application

2-Aminopurine is An inhibitor of PKR.

Definition

ChEBI: The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.

Biochem/physiol Actions

2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.

Properties of 2-Aminopurine

Melting point:	280-282 °C (lit.)
Boiling point:	238.81°C (rough estimate)
Density	1.3795 (rough estimate)
refractive index	1.7000 (estimate)
storage temp.	2-8°C
solubility	Aqueous Acid (Slightly), Methanol (Slightly, Heated)
form	Amorphous Powder
pka	8.02±0.20(Predicted)
color	Light beige
Stability:	Hygroscopic
CAS DataBase Reference	452-06-2(CAS DataBase Reference)
NIST Chemistry Reference	Purine, 2-amino-(452-06-2)