2-Amino-6-chlorobenzoic acid
Synonym(s):6-Chloroanthranilic acid
- CAS NO.:2148-56-3
- Empirical Formula: C7H6ClNO2
- Molecular Weight: 171.58
- MDL number: MFCD00051530
- EINECS: 218-416-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 2-Amino-6-chlorobenzoic acid?
Chemical properties
white to light yellow crystal powder
The Uses of 2-Amino-6-chlorobenzoic acid
2-Amino-6-chlorobenzoic acid is used as intermediate for medicine.
What are the applications of Application
The tricyclohexyltin 2-amino-6-chlorobenzoate was synthesized by the reaction of the tricyclohexyltin hydroxide with the 2-amino-6-chlorobenzoic acid.
Preparation
A, in the reaction vessel being provided with agitator, thermometer, reflux condenser, Dropping funnel, add cerium chloride 0.16mol, 4-hydroxy 3-methoxybenzene ethanol solution 0.19mol, Klorvess Liquid 400-500ml, control mixing speed and exist 160-190rpm, rising solution temperature, to 60-65°C, is slowly added to 2-chloro-6-nitrobenzoyl acid solution 0.13mol, sulfurous acid Hydrogen potassium solution 200ml, raises mixing speed to 260-310rpm, back flow reaction 5-7h;
B, reduction solution temperature, to 15-19°C, separate out solid, filter, and add diammonium hydrogen citrate solution 150-in filtrate 180ml, concentrating under reduced pressure, separate out solid, filter, dehydrant is dehydrated, brine, and pyridine solution washs, ethyl acetate solution Middle recrystallization, obtains crystal 2-amino-6-chlorobenzoic acid (C7H6ClNO2).
Properties of 2-Amino-6-chlorobenzoic acid
Melting point: | 158-160 °C (lit.) |
Boiling point: | 250°C (rough estimate) |
Density | 1.3246 (rough estimate) |
refractive index | 1.5560 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
form | Crystalline Powder |
pka | 0.97±0.10(Predicted) |
color | Light yellow to beige |
Water Solubility | Very soluble in water. Soluble in methanol. |
BRN | 2804041 |
CAS DataBase Reference | 2148-56-3(CAS DataBase Reference) |
NIST Chemistry Reference | 2-Amino-6-chlorobenzoic acid(2148-56-3) |
Safety information for 2-Amino-6-chlorobenzoic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Amino-6-chlorobenzoic acid
InChIKey | SZCPTRGBOVXVCA-UHFFFAOYSA-N |
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