2-Amino-5-fluorobenzoic acid
Synonym(s):5-Fluoroanthranilic acid
- CAS NO.：446-08-2
- Empirical Formula: C7H6FNO2
- Molecular Weight: 155.13
- MDL number: MFCD00055566
- EINECS: 207-159-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-29 15:17:36
What is 2-Amino-5-fluorobenzoic acid?
Chemical properties
white to light yellow crystal powder
The Uses of 2-Amino-5-fluorobenzoic acid
2-Amino-5-fluorobenzoic acid is used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs.
The Uses of 2-Amino-5-fluorobenzoic acid
Used in the synthesis of styrylquinazolinones which are potential anticancer agents.
What are the applications of Application
5-Fluoroanthranilic Acid is an antimetabolite for the tryptophan pathway in yeast
Definition
ChEBI: An aminobenzoic acid that is anthranilic acid in which the hydrogen at position 5 on the phenyl ring is replaced by fluorine.
Properties of 2-Amino-5-fluorobenzoic acid
| Melting point: | 181-183 °C(lit.) |
| Boiling point: | 223.67°C (rough estimate) |
| Density | 1.3021 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Fine Crystalline Powder |
| pka | 1.86±0.10(Predicted) |
| color | Light yellow to light brown |
| BRN | 2803664 |
| InChI | InChI=1S/C7H6FNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11) |
| CAS DataBase Reference | 446-08-2(CAS DataBase Reference) |
Safety information for 2-Amino-5-fluorobenzoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Amino-5-fluorobenzoic acid
| InChIKey | FPQMGQZTBWIHDN-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(F)=CC=C1N |
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