2-AMINO-5-FLUOROACETOPHENONE

CAS NO.：2343-25-1
Empirical Formula: C8H8FNO
Molecular Weight: 153.15
MDL number: MFCD09835333
SAFETY DATA SHEET (SDS)
Update Date: 2023-01-11 10:46:38

What is 2-AMINO-5-FLUOROACETOPHENONE?

The Uses of 2-AMINO-5-FLUOROACETOPHENONE

2-Amino-5-fluoroacetophenone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

Synthesis_2343-25-1
600 g of 2-ethynyl-4-fluoroaniline and 4 L of water were added to the reaction flask, and then 476 g of hydrochloric acid (concentration: 35%) was added, and thereaction was carried out at 50 ??C for 36 hours.After the reaction, the temperature is lowered to 20-25 ??C, the reaction solution is adjusted to pH 8-9 with 50% sodium hydroxide solution, thetemperature is controlled to not exceed 30 ??C during pH adjustment, and the filter cake is washed with 1 L of water and decompressed at 50 ??C. After drying for 12 h, 622 g of pale yellow solid was obtained, yield91.4%.HPLC purity was 99.2%.

Properties of 2-AMINO-5-FLUOROACETOPHENONE

Melting point:	64-65 °C
Boiling point:	264.2±20.0 °C(Predicted)
Density	1.201±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	2.37±0.10(Predicted)

Safety information for 2-AMINO-5-FLUOROACETOPHENONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.