2-Amino-4,6-dimethylpyridine

Synonym(s):6-Amino-2,4-lutidine

CAS NO.：5407-87-4
Empirical Formula: C7H10N2
Molecular Weight: 122.17
MDL number: MFCD00006322
EINECS: 226-470-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:52

What is 2-Amino-4,6-dimethylpyridine?

Chemical properties

White to off-white crystalline

The Uses of 2-Amino-4,6-dimethylpyridine

2-Amino-4,6-dimethylpyridine, can be used in the synthesis of various chemical compounds having therapeutic activity, such as in preparation of quinoline and quinoxaline compounds having anticancer activity.

The Uses of 2-Amino-4,6-dimethylpyridine

Organic intermediate.

What are the applications of Application

2-Amino-4,6-dimethylpyridine is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandins and leukotrienes. 2-Amino-4,6-dimethylpyridine binds to the cyclooxygenase enzyme and blocks its conversion of arachidonic acid to prostaglandin H2. This compound has been shown to have potent inhibitory effects against Leishmania, with high values in reactive compounds. The molecular modeling of this compound shows that it has an unpaired amino function and an amide.

Purification Methods

Recrystallise this base from hexane, ether/pet ether or *benzene. Residual *benzene is removed over paraffin-wax chips in an evacuated desiccator. The dipicrate crystallises from EtOH and has m 205-207o(dec). [Beilstein 22 III/IV 4210.]

Properties of 2-Amino-4,6-dimethylpyridine

Melting point:	63-64 °C (lit.)
Boiling point:	235 °C (lit.)
Density	1.0959 (rough estimate)
refractive index	1.6100 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	Crystalline Powder
pka	7.62±0.35(Predicted)
color	White to light brown
InChI	InChI=1S/C7H10N2/c1-5-3-6(2)9-7(8)4-5/h3-4H,1-2H3,(H2,8,9)
CAS DataBase Reference	5407-87-4(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridinamine, 4,6-dimethyl-(5407-87-4)
EPA Substance Registry System	2-Pyridinamine, 4,6-dimethyl- (5407-87-4)

Safety information for 2-Amino-4,6-dimethylpyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.