2-Amino-4-bromophenol

Synonym(s):4-Bromo-2-aminophenol;NSC 523846

CAS NO.：40925-68-6
Empirical Formula: C6H6BrNO
Molecular Weight: 188.02
MDL number: MFCD00235171
EINECS: 627-173-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-29 14:58:39

What is 2-Amino-4-bromophenol?

Description

2-Amino-4-bromophenol is a reactant for the preparation of (aryl)oxadiazolobenzoxazinones via Suzuki-Miyaura reaction, copper-catalyzed oxidative amination of benzoxazoles and related azoles via C-H and C-N bond activation synthesis of N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as protein tyrosine phophatase 1B inhibitors,preparation of lipophilic deoxy-xylulose-phosphate reductoisomerase inhibitors,synthesis of benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase.

Chemical properties

White solid

The Uses of 2-Amino-4-bromophenol

Reactant for:

Preparation of (aryl)oxadiazolobenzoxazinones via Suzuki-Miyaura reaction
Copper-catalyzed oxidative amination of benzoxazoles and related azoles via C-H and C-N bond activation
Synthesis of N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as protein tyrosine phophatase 1B inhibitors
Preparation of lipophilic deoxy-xylulose-phosphate reductoisomerase inhibitors
Synthesis of benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase

What are the applications of Application

2-Amino-4-bromophenol is a reactant for the preparation of (aryl)oxadiazolobenzoxazinones via Suzuki-Miyaura reaction

Properties of 2-Amino-4-bromophenol

Melting point:	135-140°C
Boiling point:	282.8±25.0 °C(Predicted)
Density	1.768±0.06 g/cm3(Predicted)
storage temp.	2-8°C
form	powder to crystal
pka	9.19±0.18(Predicted)
color	White to Gray to Brown
BRN	3236448
InChI	InChI=1S/C6H6BrNO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H,8H2
CAS DataBase Reference	40925-68-6(CAS DataBase Reference)

Safety information for 2-Amino-4-bromophenol

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.