2-Amino-3,5-dibromopyrazine

CAS NO.：24241-18-7
Empirical Formula: C4H3Br2N3
Molecular Weight: 252.89
MDL number: MFCD00673150
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-01 17:24:36

What is 2-Amino-3,5-dibromopyrazine?

Chemical properties

white to light yellow crystal powde

The Uses of 2-Amino-3,5-dibromopyrazine

2-Amino-3,5-dibromopyrazine is used in the preparation of conjugated polymers for neurotoxin detection. 2-Amino-3,5-dibromopyrazine is an intermediate in the preparation of rho kinase (ROCK) inhibitor s.

The Uses of 2-Amino-3,5-dibromopyrazine

2-Amino-3,5-dibromopyrazine may be used in the synthesis of:

2-amino-5-bromopyrazin-3-thiol
2-amino-3,5-bis(p-methoxyphenyl)-1,4-pyrazine
3,7-dihydroimidazo[1,2a]pyrazine-3-ones

General Description

2-Amino-3,5-dibromopyrazine can be synthesized from 2-aminopyrazine via bromination using N-bromosuccinimide (NBS). It reacts with sodium dicyanocuprate to form a mixture of mono and dicyanation products. The formation of 2-aminothiazolopyrazines by reacting 2-amino-3,5-dibromopyrazine with isothiocyanates has been reported.

Properties of 2-Amino-3,5-dibromopyrazine

Melting point:	114-117 °C (lit.)
Boiling point:	294.6±35.0 °C(Predicted)
Density	2.287±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	soluble in Methanol
form	Powder
pka	0.81±0.10(Predicted)
color	Yellow to brown
CAS DataBase Reference	24241-18-7(CAS DataBase Reference)

Safety information for 2-Amino-3,5-dibromopyrazine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.