2-Amino-2-methyl-1,3-propanediol

Synonym(s):2-Amino-2-methyl-1,3-propanediol;Ammediol;AMPD

CAS NO.：115-69-5
Empirical Formula: C4H11NO2
Molecular Weight: 105.14
MDL number: MFCD00004678
EINECS: 204-100-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

2-Amino-2-methyl-1,3-propanediol Structural

What is 2-Amino-2-methyl-1,3-propanediol?

Chemical properties

white powder

The Uses of 2-Amino-2-methyl-1,3-propanediol

A useful biological buffer2-Amino-2-methyl-1,3-propanediol is used to make surfactants, vulcanization accelerators and as a biological buffer. It acts as an absorbent for acidic gases and emulsifying agent for cosmetics, mineral oil, leather dressings, textile specialties and cleaning compounds. It is also used in hair sprays. It acts as a buffer for the determination of alkaline phosphatase activity and spacer in isotachophoresis of proteins. It serves as a reaction buffer for enzymes with an activity in the basic pH range such as alkaline phosphatase. Further, it is used in the preparation of 4-hydroxymethyl-4-methyl-oxazolidin-2-one.

The Uses of 2-Amino-2-methyl-1,3-propanediol

Emulsifying agent (in soap form) for oils, fats, and waxes; absorbent for acidic gases; organic synthesis; cosmetics.

What are the applications of Application

2-Amino-2-methyl-1,3-propanediol is a buffer and spacer in isotachophoresis of proteins

Definition

ChEBI: An aminodiol that is propane-1,3-diol substituted ny an amino and a methyl group at position 2.

Purification Methods

Crystallise the diol three times from MeOH, dry in a stream of dry N2 at room temperature, then in a vacuum oven at 55o. Store it over CaCl2 [Hetzer & Bates J Phys Chem 66 308 1962]. [Beilstein 4 IV 1881.]

Properties of 2-Amino-2-methyl-1,3-propanediol

Melting point:	100-110 °C (lit.)
Boiling point:	151 °C/10 mmHg (lit.)
Density	1.0509 (estimate)
vapor density	3.63 (vs air)
vapor pressure	~10 mm Hg ( 152 °C)
refractive index	1.4754 (estimate)
Flash point:	>100°C
storage temp.	Store below +30°C.
solubility	H₂O: 1 M at 20 °C, clear, colorless
form	Crystalline Powder
color	White
PH	10.0-12.0 (20℃, 0.5M in H2O)
pka	8.8(at 25℃)
PH Range	7.8 - 9.7
Water Solubility	2500 g/L (20 ºC)
λmax	λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.03
Merck	13,447
BRN	635708
Stability:	Stable. Combustible. May be moisture-sensitive. Incompatible with strong oxidizing agents, copper, aluminium, brass, strong acids.
CAS DataBase Reference	115-69-5(CAS DataBase Reference)
NIST Chemistry Reference	2-Amino-2-methyl-1,3-propanediol(115-69-5)
EPA Substance Registry System	1,3-Propanediol, 2-amino-2-methyl- (115-69-5)

Safety information for 2-Amino-2-methyl-1,3-propanediol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.