2-Acetoxy-2-methylpropionyl bromide
Synonym(s):α-Acetoxyisobutyryl bromide;2-Acetoxy-2-methylpropionyl bromide
- CAS NO.:40635-67-4
- Empirical Formula: C6H9BrO3
- Molecular Weight: 209.04
- MDL number: MFCD00040923
- EINECS: 629-266-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:42:45
What is 2-Acetoxy-2-methylpropionyl bromide?
Chemical properties
light yellow clear liquid
The Uses of 2-Acetoxy-2-methylpropionyl bromide
1-Bromocarbonyl-1-methylethyl acetate (α-Acetoxyisobutyryl bromide) may be used:
- in the chemoenzymatic synthesis of (1R,2S)-1,2-epoxy-1,2-dihydroacridine (acridine 1,2-oxide)
- in the synthesis of protected 3′-deoxyadenosine and 3′-deoxyguanosine
- as reagent for deoxygenation of vicinal diols, as well as in the preparation of 2′,3′-dideoxycytidine and other dideoxy and deoxynucleosides from the corresponding ribo series.
General Description
1-Bromocarbonyl-1-methylethyl acetate (α-Acetoxyisobutyryl bromide) participates in the conversion of adenosine to trans-3′(2′)-bromo-2′(3′)-acetates, via glycosyl cleavage.
Properties of 2-Acetoxy-2-methylpropionyl bromide
Boiling point: | 75-77 °C12 mm Hg(lit.) |
Density | 1.431 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | soluble in Chloroform, Methanol |
color | Clear, pale yellow |
Sensitive | Moisture Sensitive |
BRN | 2432585 |
CAS DataBase Reference | 40635-67-4(CAS DataBase Reference) |
Safety information for 2-Acetoxy-2-methylpropionyl bromide
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Acetoxy-2-methylpropionyl bromide
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Ethyl acetate
Ethidium bromide
2-Acetoxy-2-methylpropionyl bromide
Acetyl bromide
2-METHOXY-2-METHYLPROPYL BROMIDE
2-Bromoethyl acetate
1-BROMO-2-PROPANOL
ISOBUTYRYL BROMIDE
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