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HomeProduct name list2-Acetamidophenol

2-Acetamidophenol

Synonym(s):N-(2-Hydroxyphenyl)acetamide;2′-Hydroxyacetanilide;2-Acetamidophenol;NSC 3989

  • CAS NO.:614-80-2
  • Empirical Formula: C8H9NO2
  • Molecular Weight: 151.16
  • MDL number: MFCD00002181
  • EINECS: 210-396-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 11:41:24
2-Acetamidophenol Structural

What is 2-Acetamidophenol?

Chemical properties

white or light brown powder.soluble in hot water and ethanol, slightly soluble in cold water.

The Uses of 2-Acetamidophenol

An Acetaminophen (A161220) impurity.
2-Acetamidophenol is used as raw material to manufacture industrial organic chemicals.
Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis.

Definition

ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides.

Preparation

Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Purification Methods

Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.]

Properties of 2-Acetamidophenol

Melting point: 205-210 °C(lit.)
Boiling point: 273.17°C (rough estimate)
Density  1.2023 (rough estimate)
refractive index  1.5810 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  DMSO (Slightly), Methanol (Slightly)
form  Powder
pka 9.35±0.35(Predicted)
color  Off-white to beige to brown
BRN  607592
Stability: Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides.
InChI InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)
CAS DataBase Reference 614-80-2(CAS DataBase Reference)
NIST Chemistry Reference Acetamide, N-(2-hydroxyphenyl)-(614-80-2)
EPA Substance Registry System 2'-Hydroxyacetanilide (614-80-2)

Safety information for 2-Acetamidophenol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 2-Acetamidophenol

InChIKey ADVGKWPZRIDURE-UHFFFAOYSA-N
SMILES C(NC1=CC=CC=C1O)(=O)C

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