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HomeProduct name list2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

  • CAS NO.:1030825-20-7
  • Empirical Formula: C18H14BrFS
  • Molecular Weight: 361.27
  • MDL number: MFCD21496340
  • EINECS: 807-103-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-16 14:59:45
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Structural

What is 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene?

The Uses of 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.

Preparation

A preparation method for 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene, is characterized in that comprising the steps:

1) 2-bromothiophene and P-Bromofluorobenzene obtain 2-(4-fluorophenyl) thiophene by linked reaction;

2) 2-(4-fluorophenyl) thiophene and 2-methyl-5-bromo-benzoic acid obtain the bromo-2-aminomethyl phenyl of 5--2-(4-fluorophenyl) thiophene ketone by Friedel-Crafts reaction;

3) 5-bromo-2-aminomethyl phenyl-2-(4-fluorophenyl) thiophene ketone obtains 2-(the bromo-2-methyl-benzyl of 5-)-5-(4-fluorophenyl) thiophene through reduction reaction.

Properties of 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

Melting point: 103 °C
Boiling point: 438.3±40.0 °C(Predicted)
Density  1.388
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  DMSO (Slightly, Heated), Hexanes (Slightly, Heated)
form  Solid
color  White to Off-White

Safety information for 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

Computed Descriptors for 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

Abamectin manufacturer

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Aarti Industries Limited (AIL)

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Crams Technologies

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Rivashaa Agrotech Biopharma Pvt. Ltd.

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