[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

CAS NO.：5428-80-8
Empirical Formula: C21H21ClN2O
Molecular Weight: 352.86
MDL number: MFCD29918839
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 19:38:33

What is [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol?

Description

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC₅₀ = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

The Uses of [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

Properties of [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

Melting point:	198-199.5 °C
Boiling point:	551.4±50.0 °C(Predicted)
Density	1.244±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
form	A crystalline solid
pka	13.22±0.20(Predicted)

Safety information for [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H317:Sensitisation, Skin H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.