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HomeProduct name list2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE

2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE

2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Structural

What is 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE?

The Uses of 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE

AZ 10417808 inhibits human caspase-3 with Ki values in the 90 to 800 nM range. AZ 10417808 blocks cellular and biochemical features of apoptosis in cells.

Definition

ChEBI: 2-(3,4-dichloroanilino)-6-nitro-4-oxo-N-prop-2-enyl-1H-quinazoline-8-carboxamide is a member of quinazolines.

Biological Activity

Selective non-peptide inhibitor of caspase-3 (K i = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (K i > 10 μ M). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC 50 = 14.9 μ M).

Properties of 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE

storage temp.  Store at RT
solubility  <10.86mg/ml in DMSO
form  solid
color  Yellow

Safety information for 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE

Computed Descriptors for 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE

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