1,3-Diphenylguanidine

CAS NO.：102-06-7
Empirical Formula: C13H13N3
Molecular Weight: 211.26
MDL number: MFCD00001758
EINECS: 203-002-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-24 19:19:26

What is 1,3-Diphenylguanidine?

Chemical properties

1,3-diphenylguanidine is a white or cream powder with a slight odour and bitter taste. slightly soluble in water, soluble in ethanol, chloroform, hot benzene, hot toluene, easily soluble in dilute inorganic acids. Used as medium speed accelerator for natural rubber and synthetic rubber, mainly used in the manufacture of tires, rubber plates, rubber shoes and other rubber industrial products.

The Uses of 1,3-Diphenylguanidine

1,3-Diphenylguanidine is used as pharmaceutical intermediate.

The Uses of 1,3-Diphenylguanidine

N,N'-Diphenylguanidine is a primary standard for acids; aeeelerator for the vulcanization of rubber for use with thiazoles and sulfenamides; complexing agent in the deteetion of metals and organie bases.

Background

Diphenylguanidine is a complexing agent used in the detection of metals and organic bases and used as an accelerator in the vulcanization of rubber. It is found in some rubber products. It is also a dermatological sensitizer and allergen.
Sensitivity to diphenylguanidine may be identified with a clinical patch test.

Indications

Diphenylguanidine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older.

Definition

ChEBI: 1,3-diphenylguanidine is guanidine carrying a phenyl substituent on each of the two amino groups. It is used as an accelerator in the rubber industry. It has a role as an allergen.

General Description

White to cream-colored chalky powder. Bitter taste and slight odor.

Air & Water Reactions

Sensitive to moisture. Aqueous solutions are strongly alkaline. Insoluble in water.

Reactivity Profile

1,3-Diphenylguanidine behaves as an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. 1,3-Diphenylguanidine is incompatible with strong oxidizers.

Fire Hazard

1,3-Diphenylguanidine is combustible.

Flammability and Explosibility

Non flammable

Contact allergens

Diphenylguanidine is a rubber sensitizer that can induce immediate-type reactions and delayed-type contact allergy. It was formerly contained in “carba mix.” Occupational exposure concerns finished rubber items and the rubber manufacturing industry. The most frequent occupational categories are metal industry, homemakers, health services and laboratories, and the building industry.

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.

Metabolism

Not Available

Purification Methods

1,3-Diphenylguanidine [102-06-7] M 211.3, m 148o, 10.12. Crystallise it from toluene,

Properties of 1,3-Diphenylguanidine

Melting point:	146-148 °C(lit.)
Boiling point:	170°C
Density	1,13 g/cm³
vapor pressure	0Pa at 25℃
refractive index	1.6000 (estimate)
Flash point:	170°C
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in alcohol, chloroform, hot benzene, hot toluene, and dilute mineral acids
form	Powder
pka	pK1:10.12 (25°C)
color	Pale Cream
PH	10.2 (10g/l, H2O)
Odor	wh. powd., bitter taste, sl. odor
Water Solubility	slightly soluble
Merck	14,3324
BRN	1875653
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents. Moisture sensitive.
CAS DataBase Reference	102-06-7(CAS DataBase Reference)
NIST Chemistry Reference	Guanidine, n,n'-diphenyl-(102-06-7)
EPA Substance Registry System	1,3-Diphenylguanidine (102-06-7)

Safety information for 1,3-Diphenylguanidine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.