1,3-Diphenylguanidine

Chemical properties

1,3-diphenylguanidine is a white or cream powder with a slight odour and bitter taste. slightly soluble in water, soluble in ethanol, chloroform, hot benzene, hot toluene, easily soluble in dilute inorganic acids. Used as medium speed accelerator for natural rubber and synthetic rubber, mainly used in the manufacture of tires, rubber plates, rubber shoes and other rubber industrial products.

The Uses of 1,3-Diphenylguanidine

1,3-Diphenylguanidine is used as pharmaceutical intermediate.

The Uses of 1,3-Diphenylguanidine

N,N'-Diphenylguanidine is a primary standard for acids; aeeelerator for the vulcanization of rubber for use with thiazoles and sulfenamides; complexing agent in the deteetion of metals and organie bases.

Background

Diphenylguanidine is a complexing agent used in the detection of metals and organic bases and used as an accelerator in the vulcanization of rubber. It is found in some rubber products. It is also a dermatological sensitizer and allergen.
Sensitivity to diphenylguanidine may be identified with a clinical patch test.

Indications

Diphenylguanidine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older.

Definition

ChEBI: 1,3-diphenylguanidine is guanidine carrying a phenyl substituent on each of the two amino groups. It is used as an accelerator in the rubber industry. It has a role as an allergen.

General Description

White to cream-colored chalky powder. Bitter taste and slight odor.

Air & Water Reactions

Sensitive to moisture. Aqueous solutions are strongly alkaline. Insoluble in water.

Reactivity Profile

1,3-Diphenylguanidine behaves as an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. 1,3-Diphenylguanidine is incompatible with strong oxidizers.

Fire Hazard

1,3-Diphenylguanidine is combustible.

Flammability and Explosibility

Non flammable

Contact allergens

Diphenylguanidine is a rubber sensitizer that can induce immediate-type reactions and delayed-type contact allergy. It was formerly contained in “carba mix.” Occupational exposure concerns finished rubber items and the rubber manufacturing industry. The most frequent occupational categories are metal industry, homemakers, health services and laboratories, and the building industry.

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.

Metabolism

Not Available

Purification Methods

1,3-Diphenylguanidine [102-06-7] M 211.3, m 148o, 10.12. Crystallise it from toluene,