Fmoc-8-amino-3,6-dioxaoctanoic acid
Synonym(s):8-(Fmoc-amino)-3,6-dioxaoctanoic acid;Fmoc-8-amino-3,6-dioxaoctanoic acid;Fmoc-NH-(PEG)-COOH (9 atoms)
- CAS NO.：166108-71-0
- Empirical Formula: C21H23NO6
- Molecular Weight: 385.41
- MDL number: MFCD01321015
- EINECS: 200-111-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-18 08:51:57
What is Fmoc-8-amino-3,6-dioxaoctanoic acid?
Description
Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical properties
White solid
The Uses of Fmoc-8-amino-3,6-dioxaoctanoic acid
Hydrophillic spacer group.
The Uses of Fmoc-8-amino-3,6-dioxaoctanoic acid
8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.
What are the applications of Application
Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.
Properties of Fmoc-8-amino-3,6-dioxaoctanoic acid
| Melting point: | 90-92℃ |
| Boiling point: | 631.4±45.0 °C(Predicted) |
| Density | 1.265±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 3.40±0.10(Predicted) |
| color | White |
| InChI | InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24) |
| CAS DataBase Reference | 166108-71-0(CAS DataBase Reference) |
Safety information for Fmoc-8-amino-3,6-dioxaoctanoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Fmoc-8-amino-3,6-dioxaoctanoic acid
| InChIKey | XQPYRJIMPDBGRW-UHFFFAOYSA-N |
| SMILES | C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2 |
Abamectin manufacturer
NSJ Prayog Life Sciences Private Limited
1Y
Phone:+916281747900
Whatsapp: +91 6281747900
product: 166108-71-0 1-(9H-fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid 98%
New Products
Tubulysin I Tubulysin F Tubulysin C Potassium HMDS (1.0 M in THF) CYCLOBUTYLAMINE HYDROCHLORIDE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- Cyclobutanamine, 3,3-difluoro- (9CI) 4,4-DIFLUOROPIPERIDINE tetrahydro-4-methyl-2H-pyran 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE (3-Fluoro-4- morpholin-4-yl- phenyl)- carbamic acid methyl ester 7-chloro-1- (2-methyl-4- nitrobenzoyl)-3,4- dihydro-1H-benzo[b] azepin-5(2H)-one 2-Bromo-6- nitroanisole Lubiprostone Magnesium Trisilicate Latanoprostene Bunod 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid (R)-methyl 2-isocyano-3-(tritylthio)propanoate (2R,3S)-2-Azido-3-methylpentanoic acid Methyl (2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoate Methylprednisolone Acetate EP Impurity A BECLOMETASONE DIPROPIONATE EP IMPURITY NRelated products of tetrahydrofuran
![Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH](https://img.chemicalbook.in/CAS/20200611/GIF/1662688-20-1.gif)
You may like
-
166108-71-0 1-(9H-fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid 98%View Details
166108-71-0 -
166108-71-0 98%View Details
166108-71-0 -
![8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid CAS 166108-71-0](https://img.chemicalbook.in//Content/image/CP5.jpg)
8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid CAS 166108-71-0View Details
166108-71-0 -
Fmoc-8-amino-3,6-dioxaoctanoic acid, 99% CAS 166108-71-0View Details
166108-71-0 -
{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid CAS 166108-71-0View Details
166108-71-0 -
Fmoc-NH-(PEG)-COOH (9 atoms) CAS 166108-71-0View Details
166108-71-0 -
ethyl 2-formylthiazole-4-carboxylate 73956-17-9 99%View Details
73956-17-9 -
Tubulysin D 99%View Details
309935-57-7
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.