2-(2-Bromoethyl)-1,3-dioxolane

Synonym(s):3-Bromopropionaldehyde ethylene acetal

CAS NO.：18742-02-4
Empirical Formula: C5H9BrO2
Molecular Weight: 181.03
MDL number: MFCD00003216
EINECS: 242-551-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-24 21:11:45

2-(2-Bromoethyl)-1,3-dioxolane Structural

What is 2-(2-Bromoethyl)-1,3-dioxolane?

Chemical properties

Clear colorless to yellow or brown liquid

The Uses of 2-(2-Bromoethyl)-1,3-dioxolane

2-(2-Bromoethyl)-1,3-dioxolane is used as a pharmaceutical intermediate, dioxolanes, acetals, ketals, building blocks, chemical synthesis, organic building blocks and oxygen compounds. 1,1-(Ethylenedioxy)-3-bromopropane is used in the synthesis of EGFR inhibitors. Also used in the synthesis of orally active agents of cancer and cell proliferation with quinoline substructures. It is also used as flavouring agent.

The Uses of 2-(2-Bromoethyl)-1,3-dioxolane

Alkylating agent for amines,1 dithianes,2 and carboximides,3 and via the Grignard reagent, aldehydes.4

General Description

Copper-catalyzed borylation of 2-(2-bromoethyl)-1,3-dioxolane with bis(pinacolato)diboron followed by treatment with potassium bifluoride affords the key organotrifluoroborate reagent.

Purification Methods

Dissolve it in pentane, wash with 5% aqueous NaHCO3, dry (Na2SO4), and evaporate. Distil the residue. [NMR: Büchi & Wüest J Org Chem 34 1122 1969, Kriesat & Gisvold J Pharm Sci 60 1250 1971, Beilstein 19/1 V 69.]

Properties of 2-(2-Bromoethyl)-1,3-dioxolane

Boiling point:	68-70 °C8 mm Hg(lit.)
Density	1.542 g/mL at 25 °C(lit.)
refractive index	n20/D 1.479(lit.)
Flash point:	149 °F
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly)
form	clear liquid
Specific Gravity	1.541.542
color	brownish-yellow
Water Solubility	immiscible
Sensitive	Light Sensitive
BRN	103516
CAS DataBase Reference	18742-02-4(CAS DataBase Reference)
NIST Chemistry Reference	2-(2-Bromoethyl)-1,3-dioxolane(18742-02-4)

Safety information for 2-(2-Bromoethyl)-1,3-dioxolane

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.