2-(2-Aminoethyl)isothiourea dihydrobromide

Description

S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the K_i values are 1.8, 2.1, and 0.59 μM, respectively.

Chemical properties

Crystals, hygroscopic.

The Uses of 2-(2-Aminoethyl)isothiourea dihydrobromide

2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).

The Uses of 2-(2-Aminoethyl)isothiourea dihydrobromide

NOS inhibitor

The Uses of 2-(2-Aminoethyl)isothiourea dihydrobromide

Has radioprotective activity against x-rays.

What are the applications of Application

S-(2-Aminoethyl)-ITU dihydrobromide is a selective inhibitor of NOS2 (iNOS)

Purification Methods

Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957].

References

[1]. garvey ep, oplinger ja, tanoury gj, et al. potent and selective inhibition of human nitric oxide synthases. inhibition by non-amino acid isothioureas. j biol chem. 1994 oct 28;269(43):26669-76.