2-(2-Aminoethyl)isothiourea dihydrobromide

Synonym(s):2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide;AET;S-(2-Aminoethyl)isothiouronium bromide hydrobromide;S-(2-Aminoethyl)thiouronium bromide hydrobromide

CAS NO.：56-10-0
Empirical Formula: C3H11Br2N3S
Molecular Weight: 281.01
MDL number: MFCD00037011
EINECS: 200-257-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 21:39:59

2-(2-Aminoethyl)isothiourea dihydrobromide Structural

What is 2-(2-Aminoethyl)isothiourea dihydrobromide?

Description

S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the K_i values are 1.8, 2.1, and 0.59 μM, respectively.

Chemical properties

Crystals, hygroscopic.

The Uses of 2-(2-Aminoethyl)isothiourea dihydrobromide

2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).

The Uses of 2-(2-Aminoethyl)isothiourea dihydrobromide

NOS inhibitor

The Uses of 2-(2-Aminoethyl)isothiourea dihydrobromide

Has radioprotective activity against x-rays.

What are the applications of Application

S-(2-Aminoethyl)-ITU dihydrobromide is a selective inhibitor of NOS2 (iNOS)

Purification Methods

Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957].

References

[1]. garvey ep, oplinger ja, tanoury gj, et al. potent and selective inhibition of human nitric oxide synthases. inhibition by non-amino acid isothioureas. j biol chem. 1994 oct 28;269(43):26669-76.

Properties of 2-(2-Aminoethyl)isothiourea dihydrobromide

Melting point:	190-196 °C(lit.)
Density	1.94 g/cm3
storage temp.	Store below +30°C.
solubility	50g/l
form	powder to crystal
color	White to Almost white
Water Solubility	almost transparency
Merck	14,178
BRN	3911163
CAS DataBase Reference	56-10-0(CAS DataBase Reference)
EPA Substance Registry System	Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide (56-10-0)

Safety information for 2-(2-Aminoethyl)isothiourea dihydrobromide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.