2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
- CAS NO.:31521-83-2
- Empirical Formula: C7H16O3S
- Molecular Weight: 180.27
- MDL number: MFCD23817484
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:03
What is 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol?
The Uses of 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol can be used to prepare biofunctional silicon nanoparticles for drug delivery.
Synthesis
Toluene-4-sulfonic acid 2-[2-(2-methoxyethoxy)-ethoxy]-ethyl ester (2.7) (10.8 g, 34 mmol) and thiourea (2.6 g, 34 mmol) were dissolved in a mixture of absolute EtOH (20 mL) and H2O (14 mL) and the mixture was refluxed for 3h. 4N NaOH solution (10 mL) was added to mixture and the reaction mixture refluxed 2 more h. The reaction mixture was concentrated under reduced pressure to ~ 10 mL, diluted with distilled H2O (10 mL) and neutralized with concentrated HCl. The solution was extracted with CH2Cl2 (3x10mL) and the solvent was evaporated under reduced pressure. The pink-yellow liquid was distilled at 0.45 torr pressure. The product was collected as a clear liquid and obtained in 54% yield. B.p. 55-57 °C at 0.45 torr. GC-MS Calcd. C7H16O3S+ : 180.0; found: 179.9. 1 H NMR (250 MHz, CDCl3) δ 3.6(6H), 3.5(4H), 3.4(3H), 2.7(2H), 1.6(1H); 13 C NMR (300 MHz, CDCl3) δ 76.92, 73.30, 72.34, 70.98, 70.63, 59.46, 24.66
Properties of 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
Boiling point: | 50 °C(Press: 1 Torr) |
Density | 1.017 |
form | Liquid |
pka | 9.65±0.10(Predicted) |
color | Colorless to light yellow |
Safety information for 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
New Products
Tubulysin F Tubulysin E Tubulysin H 4,4-DIFLUOROCYCLOHEXANAMINE 3-Aminocyclobutanone hydrochloride CYCLOBUTYLAMINE HYDROCHLORIDE 2H-Pyran, 4-ethynyltetrahydro- 4-(Benzyloxy)-3-bromophenylacetic Acid Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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