(1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine

CAS NO.：167316-27-0
Empirical Formula: C21H22N2O2S
Molecular Weight: 366.48
MDL number: MFCD03095684
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine?

Chemical properties

White to slightly yellow crystalline powder

The Uses of (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine

(1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine is used as a catalyst in the synthesis of keramamine C, a carboline alkaloid that is isolated from the Okinawan sponge Amphimedon sp. (1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethanediamine is also used as a catalyst in the synthesis of Tolvaptan (T536650), a selective oral vasopressin V2-receptor agonist that is used to treat hyponatremia.

The Uses of (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine

Chiral diamine ligand for cooperative metal-Bronsted acid catalyzed greener reductive amination using hydrogen gas.

Metal-Br?nsted Acid Cooperative Catalysis for Asymmetric Reductive Amination

General Description

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Properties of (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine

Melting point:	128-131 °C (lit.)
Boiling point:	537.3±60.0 °C(Predicted)
alpha	61.5 º (C=1, CH2Cl2)
Density	1.1440 (rough estimate)
refractive index	30 ° (C=1, CHCl3)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Solubility in hot Acetonitrile (almost transparency).
form	crystal
pka	10.76±0.50(Predicted)
color	white
optical activity	[α]20/D +35°, c = 1 in chloroform
CAS DataBase Reference	167316-27-0(CAS DataBase Reference)

Safety information for (1S,2S)-(+)-N-(4-Toluenesulfonyl)-1,2-diphenylethylenediamine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.