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HomeProduct name list1400W

1400W

Synonym(s):N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride

1400W Structural

What is 1400W?

Chemical properties

White Solid

The Uses of 1400W

A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM

The Uses of 1400W

1400W selectively inhibits inducible nitric oxide synthase. W 1400 has been implicated to prevent Doxorubicin and Trastuzumab induced cardiotoxicity.

Definition

ChEBI: N-[3-(aminomethyl)benzyl]acetamidine is an aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a geroprotector and an angiogenesis inhibitor. It is a carboxamidine, an aralkylamine and a primary amino compound.

Biological Activity

Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (K d = 7 nM). Selective over nNOS and eNOS (K i values are 2 and 50 μ M respectively). Cell-permeable and active in vivo .

Properties of 1400W

Melting point: 208-220 °C
Boiling point: 301.7±44.0 °C(Predicted)
Density  1.09±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  DMSO, Methanol, Water
pka 11.33±0.50(Predicted)
form  solid
color  White to Off-White

Safety information for 1400W

Computed Descriptors for 1400W

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