1400W
Synonym(s):N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride
- CAS NO.:180001-34-7
- Empirical Formula: C10H15N3
- Molecular Weight: 177.25
- MDL number: MFCD01317835
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:35
What is 1400W?
Chemical properties
White Solid
The Uses of 1400W
A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM
The Uses of 1400W
1400W selectively inhibits inducible nitric oxide synthase. W 1400 has been implicated to prevent Doxorubicin and Trastuzumab induced cardiotoxicity.
Definition
ChEBI: N-[3-(aminomethyl)benzyl]acetamidine is an aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a geroprotector and an angiogenesis inhibitor. It is a carboxamidine, an aralkylamine and a primary amino compound.
Biological Activity
Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (K d = 7 nM). Selective over nNOS and eNOS (K i values are 2 and 50 μ M respectively). Cell-permeable and active in vivo .
Properties of 1400W
Melting point: | 208-220 °C |
Boiling point: | 301.7±44.0 °C(Predicted) |
Density | 1.09±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | DMSO, Methanol, Water |
pka | 11.33±0.50(Predicted) |
form | solid |
color | White to Off-White |
Safety information for 1400W
Computed Descriptors for 1400W
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