1,4-Phenylene diisocyanate

CAS NO.：104-49-4
Empirical Formula: C8H4N2O2
Molecular Weight: 160.13
MDL number: MFCD00002025
EINECS: 203-207-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-13 09:40:06

What is 1,4-Phenylene diisocyanate?

Chemical properties

white to light yellow crystals

The Uses of 1,4-Phenylene diisocyanate

1,4-Phenylene diisocyanate has been used:

as croos-linking reagent to investigate the mechanism of enzyme immobilization on silanized surfaces
in the synthesis of dipodal bis-urea receptor, a selective receptor for hydrogen sulfate
in deposition of polyurea resists films via molecular layer deposition

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 7, p. 177, 1970 DOI: 10.1002/jhet.5570070126

General Description

White crystals or pale yellow chunky solid. Pungent odor.

Air & Water Reactions

Reacts slowly with water to form CO2

Reactivity Profile

1,4-Phenylene diisocyanate is sensitive to moisture. 1,4-Phenylene diisocyanate is incompatible with water, strong acids, strong alkalis, strong oxidizers, alcohol, amines and other hydrogen compounds.

Fire Hazard

1,4-Phenylene diisocyanate is combustible.

Flammability and Explosibility

Not classified

Properties of 1,4-Phenylene diisocyanate

Melting point:	96-99 °C (lit.)
Boiling point:	260 °C (lit.)
Density	1.3848 (rough estimate)
vapor pressure	<0.01 mm Hg ( 20 °C)
refractive index	1.4900 (estimate)
Flash point:	>230 °F
solubility	THF: soluble
form	powder to crystal
color	White to Light yellow
Water Solubility	130mg/L at 20℃
Stability:	Stable. Combustible. Incompatible with strong oxidising agents, strong alkalies, strong acids, alcohols, amines. Moisture sensitive.
CAS DataBase Reference	104-49-4(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1,4-diisocyanato-(104-49-4)
EPA Substance Registry System	1,4-Phenylene diisocyanate (104-49-4)

Safety information for 1,4-Phenylene diisocyanate

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H334:Sensitisation, respiratory H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.