1,3-Dichloro-2-propanol

Synonym(s):Glycerol-α,γ-dichlorohydrin

CAS NO.：96-23-1
Empirical Formula: C3H6Cl2O
Molecular Weight: 128.99
MDL number: MFCD00000951
EINECS: 202-491-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:57

What is 1,3-Dichloro-2-propanol?

Chemical properties

Colorless to light yellow liqui

Chemical properties

There are 4 isomers of dichloropropanols 1,3- dichloro-2-propanol (96-23-1) and “dichloropropanols” (26545-73-3) are citations in environmental regulations: C3H6OCl2 is a colorless viscous liquid with a chloroformlike odor. Slightly soluble in water. 1,3-Dichloro-2- propanol:

The Uses of 1,3-Dichloro-2-propanol

1,3-Dichloro-2-propanol biotransformation to epichlorohydrin by the whole cells of recombinant Escherichia coli via resin-based in situ product removal has been investigated. It is used in the synthesis of glycerol, in the production of plastics and textiles and in the synthesis of pharmaceuticals. Also used as a solvent and as a cement for celluloid. It is also present in some foods, e.g. soy sauce, soup spices and instant soups, from hydrolization of proteins.

The Uses of 1,3-Dichloro-2-propanol

A labelled chloropropanol which shows toxic effects.

The Uses of 1,3-Dichloro-2-propanol

A chloropropanol which shows toxic effects.

Definition

ChEBI: 1,3-dichloropropan-2-ol is a secondary alcohol that is isopropanol in which one hydrogen of each methyl group is substituted by a chlorine. A liquid at room temperature (melting point -4℃, boiling point 174℃ at 760 mm Hg), it is used as a solvent for hard resins and nitrocellulose. It has a role as a protic solvent and a cross-linking reagent. It is a secondary alcohol and an organochlorine compound.

General Description

Colorless to yellow slightly viscous liquid with an ethereal odor.

Air & Water Reactions

Water soluble.

Reactivity Profile

Sensitive to heat. Incompatible with oxidizers. Also incompatible with strong acids, strong reducing agents, acid chlorides and acid anhydrides.

Fire Hazard

1,3-Dichloro-2-propanol is combustible.

Flammability and Explosibility

Not classified

Safety Profile

Suspected carcinogen. Poison by ingestion and inhalation. Moderately toxic by skin contact. Human mutation data reported. A skin irritant. Action may be similar to that of carbon tetrachloride, but more irritating to mucous membranes. Flammable when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, dry chemical, fog, mist, or spray. Dangerous; when heated to decomposition it emits highly toxic fumes of Cl and phosgene.

Potential Exposure

It is used as a solvent for hard resins and nitrocellulose; in the manufacture of photographic chemicals and lacquer; as a cement for celluloid; and as a binder of water colors. It occurs in effluents from glycerol and halohydrin production plants.

Shipping

UN2750 1,3-Dichloropropanol-2, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires orexplosions. Keep away from alkaline materials, strong acids, acid anhydrides, strong bases

Properties of 1,3-Dichloro-2-propanol

Melting point:	-4 °C
Boiling point:	174.3 °C(lit.)
Density	1.363 g/mL at 20 °C
vapor pressure	1.5hPa at 20℃
refractive index	n20/D 1.483(lit.)
Flash point:	186 °F
storage temp.	2-8°C
solubility	water: soluble10 part
form	Liquid
pka	12.87±0.20(Predicted)
color	Clear colorless to slightly yellow
Water Solubility	soluble. >=10 g/100 mL at 23 ºC
Merck	14,3074
BRN	1732063
Dielectric constant	47.2（0℃）
CAS DataBase Reference	96-23-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Propanol, 1,3-dichloro-(96-23-1)
IARC	2B (Vol. 101) 2013
EPA Substance Registry System	1,3-Dichloro-2-propanol (96-23-1)

Safety information for 1,3-Dichloro-2-propanol

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H301:Acute toxicity,oral H312:Acute toxicity,dermal H350:Carcinogenicity
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.