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HomeProduct name list1(2H)-Phthalazinone

1(2H)-Phthalazinone

Synonym(s):Benzo[d]pyridazin-1(2H)one

  • CAS NO.:119-39-1
  • Empirical Formula: C8H6N2O
  • Molecular Weight: 146.15
  • MDL number: MFCD00006892
  • EINECS: 204-319-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:07:02
1(2H)-Phthalazinone Structural

What is 1(2H)-Phthalazinone?

Chemical properties

Off-white to pale yellow crystalline powder

The Uses of 1(2H)-Phthalazinone

Phthalazone is a remarkable scaffold in drug discovery. Also, functions as an oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase.

Definition

ChEBI: Phthalazin-1(2H)-one is a member of phthalazines.

General Description

Pale yellow crystals. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for 1(2H)-Phthalazinone are not available. 1(2H)-Phthalazinone is probably combustible.

Purification Methods

Phthalazone crystallises from H2O or EtOH and sublimes in vacuo. [Beilstein 24 H 142, 24 24 III/IV 400.]

Properties of 1(2H)-Phthalazinone

Melting point: 183-185 °C(lit.)
Boiling point: 337°C(lit.)
Density  1.2312 (rough estimate)
refractive index  1.4900 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form  Crystalline Powder
pka 12.29±0.20(Predicted)
color  Off-white to pale yellow
BRN  3654
CAS DataBase Reference 119-39-1(CAS DataBase Reference)
EPA Substance Registry System 1(2H)-Phthalazinone (119-39-1)

Safety information for 1(2H)-Phthalazinone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 1(2H)-Phthalazinone

InChIKey IJAPPYDYQCXOEF-UHFFFAOYSA-N

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