1,2-PHENYLENE PHOSPHOROCHLORIDITE

Synonym(s):o-Phenylene chlorophosphite;2-Chloro-1,3,2-benzodioxaphosphole;Chloro(1,2-phenylenedioxy)phosphine;Cyclic o-phenylene phosphorochloridite;Phosphorochloridous acid orthophenylene ester

CAS NO.：1641-40-3
Empirical Formula: C6H4ClO2P
Molecular Weight: 174.52
MDL number: MFCD00005853
EINECS: 216-690-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:04

1,2-PHENYLENE PHOSPHOROCHLORIDITE Structural

What is 1,2-PHENYLENE PHOSPHOROCHLORIDITE?

Chemical properties

Colourless Liquid Which Solidifies at Low Temperature

The Uses of 1,2-PHENYLENE PHOSPHOROCHLORIDITE

Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs

The Uses of 1,2-PHENYLENE PHOSPHOROCHLORIDITE

Catalyst in synthesis of bakkane sesquiterpenes
Reactant in reversible halogen-halogen ligand substitution at room temperature, and in irreversible halogen-O substitution at higher temperatures
Reactant in preparation of gold(I) trimethoxybenzonitrile phosphine isolated precatalysts
Reactant for preparation of pyrroles by TMSOTf-catalyzed Arbuzov reaction
Phosphorylation agent
Reactant for reparation of vinyl-substituted spirophosphoranes and vinylphosphonates via Markovnikov addition

Properties of 1,2-PHENYLENE PHOSPHOROCHLORIDITE

Melting point:	30-35 °C(lit.)
Boiling point:	80 °C20 mm Hg(lit.)
Density	1.466 g/mL at 25 °C(lit.)
refractive index	n20/D 1.571(lit.)
Flash point:	>230 °F
storage temp.	0-6°C
solubility	Benzene (Slightly), Chloroform (Slightly)
form	solid
Sensitive	Moisture Sensitive
BRN	135455
Stability:	Moisture Sensitive
CAS DataBase Reference	1641-40-3(CAS DataBase Reference)
EPA Substance Registry System	1,3,2-Benzodioxaphosphole, 2-chloro- (1641-40-3)

Safety information for 1,2-PHENYLENE PHOSPHOROCHLORIDITE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.